Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 3 reviews · Neonatal · Headline outcomes only

No studies found 0 · 0%GRADE not reported 2 · 11.1%Very low 2 · 11.1%Low 3 · 16.7%Moderate 7 · 38.9%High 4 · 22.2%

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Sepsis without a source · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing showed no clear difference in sepsis without a source compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Catheter‐related blood stream infection · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing showed no clear difference in catheter‐related blood stream infection compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Catheter colonisation · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing probably leads to lower catheter colonisation compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Adverse effects: contact dermatitis · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing probably leads to higher adverse effects: contact dermatitis compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Four per cent chlorhexidine + hand hygiene promotion vs usual care

Authors reported adverse outcomes (events without hospitalisation) · Neonates and caregivers

It is very uncertain whether four per cent chlorhexidine + hand hygiene promotion changes authors reported adverse outcomes (events without hospitalisation) compared with usual care (very low certainty).

1 finding from 1 review