Cochrane · systematic review · CD007835
Chlorhexidine skin or cord care for prevention of mortality and infections in neonates
Sinha, A, Sazawal, S, Pradhan, A, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 16.7%Very low 0 · 0%Low 3 · 25%Moderate 3 · 25%High 4 · 33.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Preventive newborn cord cleansing in hospitals
Population: Term or late preterm newborns born in hospitals
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal mortality | RR 0.11 [0.01, 2.04] | 1 study · 140 participants | Low Downgraded: imprecision |
Omphalitis (infections) | RR 0.48 [0.28, 0.84] | 2 studies · 809 participants | Moderate Downgraded: risk of bias, imprecision |
Preventive newborn skin cleansing in hospitals
Population: Term or late preterm newborns born in hospitals
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal mortality | no estimate extracted | 0 studies · 0 participants | Ungraded |
Omphalitis | RR 0.88 [0.56, 1.39] | 2 studies · 642 participants | Low Downgraded: risk of bias |
Preventive newborn cord cleansing in the community
Population: Term or late preterm newborns born at home
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal mortality | RR 0.81 [0.71, 0.92] | 3 studies · 31084 participants | High |
Omphalitis | RR 0.48 [0.4, 0.57] | 3 studies · 39925 participants | High |
Preventive newborn skin cleansing in the community
Population: Term or late preterm newborns born at home
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal mortality | RR 1.03 [0.87, 1.23] | 1 study · 17530 participants | High |
Omphalitis | no estimate extracted | 0 studies · 0 participants | Ungraded |
Preventive maternal vaginal chlorhexidine in addition to total body cleansing in hospitals
Population: Term or late preterm newborns born in hospitals
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal mortality | RR 0.98 [0.67, 1.42] | 1 study · 4904 participants | Moderate Downgraded: imprecision |
Infections | RR 0.98 [0.82, 1.16] | 2 studies · 13033 participants | High |
Preventive maternal vaginal chlorhexidine in addition to total body cleansing in the community
Population: Term or late preterm newborns born at home
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal mortality | RR 0.2 [0.01, 4.03] | 1 study · 202 participants | Low Downgraded: imprecision |
Infections | RR 0.69 [0.49, 0.95] | 1 study · 203 participants | Moderate Downgraded: imprecision |