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Evidence found and GRADE certainty

17 questions · 18 findings · 4 reviews · All outcomes

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CD4+ T-cell count below 250 cells/mm3 vs CD4+ T-cell count >=250 cells/mm3

HIV-related oral lesions · Children and adolescents living with HIV on ART/HAART

Lower CD4+ counts (<250 cells/mm3) were associated with roughly twice the odds of HIV-related oral lesions in two studies (not pooled).

1 finding from 1 review
  • Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomes
    Cross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · CD4+ T-cell count <250 cells/mm3 vs higher
    CLWH with CD4+ <250 cells/mm3 were about twice as likely to have HIV-related oral lesions: Baghirath 2013 OR 1.916 (95% CI 0.613 to 2.513), p=0.001; Divakar 2015 OR 1.999 (95% CI 0.129 to 3.688), p=0.001. Not pooled.
    2 studies
    GRADE not reported

CD4+ T-cell count below 250 cells/mm3

HIV-related oral lesions · Children living with HIV receiving ART

One reported study did not show a clear difference in HIV-related oral lesions for children with CD4+ T-cell counts below 250 cells/mm3.

2 findings from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Major bleeding, requiring transfusion of packed red blood cells · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs standard local care

Major bleeding, requiring transfusion of packed red blood cells · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in major bleeding requiring transfusion of packed red blood cells compared with standard care (usual local haemostatic measures: gelatin sponge and…; GRADE not reported.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Major bleeding, requiring transfusion of packed red blood cells · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in major bleeding requiring transfusion of packed red blood cells compared with placebo (placebo solution/mouthwash); GRADE not reported.

1 finding from 1 review

Job-related or family-related stress and pessimistic attitude to life vs Lower stress and no pessimistic attitude

Periodontal disease and serum IL-1β IL-6 and cortisol · Patients with aggressive or chronic periodontitis at a university periodontology department

No correlation was reported between immunological markers cortisol and registered stress values; untreated aggressive periodontitis was accompanied by pessimistic attitude and elevated serum IL-6.

1 finding from 1 review

Perceived psychosocial stress vs No or lower perceived stress

GCF elastase activity and non-surgical periodontal treatment outcome (salivary cortisol, ICTP measured; no effect reported) · Adults with periodontitis needing non-surgical periodontal treatment

In one 6-month longitudinal study, patients under psychosocial stress had higher gingival crevicular fluid elastase and poorer outcomes after non-surgical periodontal therapy; not pooled (ungraded).

1 finding from 1 review

Depression and social isolation (psychosocial strain) vs No depression or lower psychosocial strain

Antibody titres to periodontal pathogens · Adults with periodontitis

In one case-control study, depression as a marker of social isolation was associated with elevated antibody titres to periodontal pathogens at baseline and 1-year follow-up; not pooled (ungraded).

1 finding from 1 review

Intervention not reported

Serum inflammatory cytokines (IL-1b, IL-6) and cortisol in periodontitis
1 finding from 1 review

High maternal allostatic load (chronic stress) and low socioeconomic status vs Lower maternal allostatic load

Dental caries in children · Mother-child pairs

In one cross-sectional study, higher maternal allostatic load was associated with child dental caries experience and with health-related maternal care-taking behaviours; not pooled (ungraded).

1 finding from 1 review

Low socioeconomic status and family financial stress vs Higher socioeconomic status and lower stress

Salivary cortisol, cariogenic bacterial load and dental caries · Kindergarten-age children

In one cross-sectional study of children, low socioeconomic status, higher basal salivary cortisol and higher cariogenic bacterial counts were each independently associated with higher dental caries risk; not pooled (ungraded).

1 finding from 1 review

Low socioeconomic position and adverse behavioural factors vs Higher socioeconomic position and fewer adverse behaviours

Systemic inflammation (C-reactive protein) and periodontal disease progression · General-population adults (German cohort)

In one 5-year longitudinal study, accumulation of low socioeconomic and behavioural factors was associated with greater periodontal disease progression and higher C-reactive protein; not pooled (ungraded).

1 finding from 1 review