Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

859 questions · 901 findings · 80 reviews

No studies found 247 · 27.4%GRADE not reported 170 · 18.9%Very low 224 · 24.9%Low 136 · 15.1%Moderate 90 · 10%High 34 · 3.8%

CERA vs other ESA

Final Hb · patients with the anaemia of end‐stage kidney disease undergoing dialysis
3 findings from 1 review

CERA vs other ESA

All‐cause mortality: CERA every 2 weeks versus rHuEPO · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in all‐cause mortality: CERA every 2 weeks versus rHuEPO compared with other ESA (moderate certainty).

1 finding from 1 review

CERA vs other ESA

Transfusions: CERA every 2 weeks versus rHuEPO · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in transfusions: CERA every 2 weeks versus rHuEPO compared with other ESA (moderate certainty).

1 finding from 1 review

CERA vs other ESA

Adverse events: hypertension · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in numbers of adverse events due to hypertension: CERA every 2 weeks… compared with other ESA (high certainty).

1 finding from 1 review

CERA vs other ESA

Numbers of adverse events due to access thrombosis · patients with the anaemia of end‐stage kidney disease undergoing dialysis

CERA showed no clear difference in numbers of adverse events due to access thrombosis: CERA every 2… compared with other ESA (moderate certainty).

1 finding from 1 review

Denzir all-ceramic FDP vs In-Ceram Zirconia all-ceramic FDP

Reconstruction failure / chip fractures (12 months) · Patients with all-ceramic implant FDP reconstructions; parallel group, 12-month
1 finding from 1 review

Alternative alloy FDP (e.g., Ceramalloy II / base-metal / palladium-silver) vs High-gold content control alloy FDP (Olympia)

Restoration survival · Patients receiving crowns and FDPs; split-mouth, 10-year

Alternative alloy FDP (e.g., Ceramalloy II / base-metal /… led to higher restoration survival (Ceramalloy II versus Olympia) compared with high-gold content control alloy FDP (Olympia); GRADE not reported.

1 finding from 1 review

Ulcerative colitis (UC) vs Healthy controls without IBD

Periodontal disease (periodontitis) coincidence · Patients with ulcerative colitis (UC) and controls without IBD; adults, both sexes

Patients with ulcerative colitis have about 3-fold higher odds of periodontal disease than controls (pooled OR 3.25, 95% CI 2.23-4.74; 5 studies; ungraded).

1 finding from 1 review

Metal-free FDPs (zirconia ceramic) vs Metal-ceramic FDPs

Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)

The review found no eligible studies for this question.

1 finding from 1 review
  • No data were presented for any of the pre-specified secondary outcomes. The trial registered pocket depth, bleeding on probing and mobility at follow-up visits but did not report the data.
    0 studies
    No studies found

Metal-free FDPs (zirconia ceramic) vs Metal-ceramic FDPs

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)

It is very uncertain whether metal-free FDPs (zirconia ceramic) changes aesthetic evaluation (patient aesthetic satisfaction changes) compared with metal-ceramic FDPs (very low certainty).

1 finding from 1 review

Adhesive flash-free ceramic brackets vs Adhesive precoated ceramic brackets

Enamel demineralization (QLF ΔF) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Flash-free brackets showed no clinical WSL reduction, with certainty not graded.

1 finding from 1 review

'Driving whilst intoxicated' programme + incarceration vs incarceration alone

Reconviction (for drink‐driving) Assessed by: Cox regression of re‐arrest rates over 24 months Timing of assessment: 24 months · adults with antisocial personality disorder

It is very uncertain whether 'Driving whilst intoxicated' programme + incarceration changes reconviction (for drink‐driving) Assessed by: Cox regression of… compared with incarceration alone (very low certainty).

1 finding from 1 review