Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 23 findings · 5 reviews · Drugs and Alcohol

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 8.7%Low 4 · 17.4%Moderate 15 · 65.2%High 2 · 8.7%

Anticonvulsant vs placebo

Alcohol Withdrawal Seizures post treatment ‐ Any Anticonvulsant vs. Placebo · people with alcohol withdrawal

Anticonvulsant showed no clear difference in alcohol Withdrawal Seizures post treatment ‐ Any Anticonvulsant vs.… compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs other drugs

Alcohol withdrawal seizures ‐ Any Anticonvulsant vs any Other · people with alcohol withdrawal

Anticonvulsant showed no clear difference in alcohol withdrawal seizures ‐ Any Anticonvulsant vs any Other compared with other Drugs (low certainty).

1 finding from 1 review

Anticonvulsant vs other drugs

Adverse events ‐ Any Anticonvulsant vs any Other · people with alcohol withdrawal

Anticonvulsant showed no clear difference in adverse events ‐ Any Anticonvulsant vs any Other compared with other Drugs (moderate certainty).

1 finding from 1 review

Anticonvulsant vs other drugs

Leaving the study early · people with alcohol withdrawal

Anticonvulsant showed no clear difference in dropout ‐ Any Anticonvulsant vs any Other compared with other Drugs (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Alcohol Withdrawal Seizures post treatment ‐ Phenytoin vs. Placebo · people with alcohol withdrawal

Anticonvulsant showed no clear difference in alcohol Withdrawal Seizures post treatment ‐ Phenytoin vs. Placebo compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Adverse events · people with alcohol withdrawal

Anticonvulsant showed no clear difference in adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Leaving the study early · patients with alcohol dependence

Anticonvulsants showed no clear difference in dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Continuous abstinence rate at · patients with alcohol dependence

Anticonvulsants showed no clear difference in continuous abstinence compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with alcohol dependence

Anticonvulsants showed no clear difference in adverse events—withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Dropout · patients with cocaine dependence

Any anticonvulsant showed no clear difference in dropout Number of participants who did not complete the treatment compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Number of participants using cocaine during the treatment (as days/week by urine tests or self report) Number of participants that reported the use of cocaine during the treatment · patients with cocaine dependence

Any anticonvulsant showed no clear difference in use of cocaine (self reported or objective) Number of participants… compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Participants with at least some Side Effects · patients with cocaine dependence

Any anticonvulsant may leads to higher side effect Number of participants reporting at least 1 side effect… compared with placebo (low certainty).

1 finding from 1 review

Benzodiazepines vs Other Drug for

Alcohol withdrawal seizures ‐ Benzodiazepine vs. Anticonvulsant · patients with

Benzodiazepine showed no clear difference in alcohol withdrawal seizures ‐ Benzodiazepine vs. Anticonvulsant compared with other Drug for (moderate certainty).

1 finding from 1 review