Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

52 questions · 55 findings · 7 reviews · Pain, Palliative and Supportive Care

No studies found 10 · 18.2%GRADE not reported 0 · 0%Very low 31 · 56.4%Low 7 · 12.7%Moderate 4 · 7.3%High 3 · 5.5%

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

Number of participants reporting an adverse event · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants reporting or experiencing any adverse event compared with active comparator (acetaminophen) (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Ibuprofen 300 mg vs paracetamol

At least 50% reduction in pain · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen 300 mg changes number of participants with at least 50% pain relief at 4 hours compared with active comparator (acetaminophen) (very low certainty).

2 findings from 1 review

Intervention not reported

Participants with at least 30% or at least 50% reduction in pain · people with cancer pain
1 finding from 1 review

Intervention not reported

PGIC much or very much improved · people with cancer pain
1 finding from 1 review

Intervention not reported

Mean pain intensity at end of study · people with cancer pain
1 finding from 1 review

Intervention not reported

Pain no worse than mild at one or two weeks (or equivalent) · people with cancer pain
1 finding from 1 review

Intervention not reported

Mean quality of life or "well‐being" · people with cancer pain
1 finding from 1 review

Intervention not reported

Participant preference · people with cancer pain
1 finding from 1 review

Intervention not reported

Serious adverse events · people with cancer pain
1 finding from 1 review