Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 6 reviews · Neonatal · Headline outcomes only

No studies found 0 · 0%GRADE not reported 1 · 10%Very low 4 · 40%Low 4 · 40%Moderate 0 · 0%High 1 · 10%

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Cranial ultrasound abnormalities (IVH grade ≥ 3 or cystic periventricular leukomalacia) · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes cranial ultrasound abnormalities (IVH grade ≥ 3 or cystic… compared with face mask (very low certainty).

1 finding from 1 review

Individual tailored vs continuous tapered dexamethasone regimen

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

Individual tailored showed no clear difference in death or abnormal neurodevelopmental outcome (various definitions) compared with continuous tapered dexamethasone regimen (low certainty).

1 finding from 1 review

Lower vs higher cumulative dose dexamethasone regimen

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

It is very uncertain whether lower changes death or abnormal neurodevelopmental outcome (various definitions)… compared with higher cumulative dose dexamethasone regimen (very low certainty).

1 finding from 1 review

Later vs earlier initiation of dexamethasone therapy

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

Later showed no clear difference in death or abnormal neurodevelopmental outcome (various definitions) compared with earlier initiation of dexamethasone therapy (low certainty).

1 finding from 1 review

Pulse vs continuous dexamethasone therapy

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

It is very uncertain whether pulse changes death or abnormal neurodevelopmental outcome (various definitions) compared with continuous dexamethasone therapy (very low certainty).

1 finding from 1 review

Intervention not reported

Cranial ultrasound abnormalities ‒intraventricular haemorrhage grade 3 to 4 · infants below 33 weeks of postmenstrual age who required resuscitation in the delivery room

It is very uncertain whether the intervention changes cranial ultrasound abnormalities ‒intraventricular haemorrhage grade… (very low certainty).

1 finding from 1 review

Use of initial sustained inflation vs standard inflations

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants resuscitated by PPV at birth

Use of initial sustained inflation showed no clear difference in cranial ultrasound abnormalities ‒Intraventricular haemorrhage grade… compared with standard inflations (low certainty).

1 finding from 1 review