Cochrane · systematic review · CD011891
Fluid supplementation for neonatal unconjugated hyperbilirubinaemia
Lai, NM, Ahmad Kamar, A, Choo, YM, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 0 · 0%Low 2 · 28.6%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intravenous fluid supplementation versus no fluid supplementation for neonatal unconjugated hyperbilirubinaemia
Population: newborn infants with unconjugated hyperbilirubinaemia undergoing phototherapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of acute bilirubin encephalopathy Intravenous fluid supplementation vs no fluid supplementation | no estimate extracted | 1 study · 74 participants | Ungraded |
Bilirubin level (μmol/L): 4 hours postintervention Intravenous fluid supplementation vs no fluid supplementation | no estimate extracted | 1 study · 67 participants | Low Downgraded: indirectness |
Proportion of infants who required exchange transfusion Intravenous fluid supplementation vs no fluid supplementation | RR 0.39 [0.21, 0.71] | 6 studies · 462 participants | Low Downgraded: imprecision, inconsistency, indirectness, publication bias |
Frequency of breastfeeding per day: day 3 Intravenous fluid supplementation vs no fluid supplementation | no estimate extracted | 1 study · 60 participants | Moderate Downgraded: imprecision, inconsistency, indirectness, publication bias |
Intravenous fluid supplementation versus oral fluid supplementation for neonatal unconjugated hyperbilirubinaemia
Population: newborn infants with unconjugated hyperbilirubinaemia undergoing phototherapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of infants with abnormal neurological signs Intravenous fluid supplementation vs oral fluid supplementation | no estimate extracted | 1 study · 54 participants | Ungraded |
Bilirubin level (μmol/L): 4 hours postphototherapy Intravenous fluid supplementation vs oral fluid supplementation | no estimate extracted | 1 study · 54 participants | Moderate Downgraded: indirectness |
Rate of change in bilirubin (μmol/L/hour): during the first 4 hours of admission Intravenous fluid supplementation vs oral fluid supplementation | no estimate extracted | 1 study · 54 participants | Moderate Downgraded: indirectness |