Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

37 questions · 38 findings · 11 reviews · Gynaecology and Fertility · Headline outcomes only

No studies found 11 · 28.9%GRADE not reported 1 · 2.6%Very low 10 · 26.3%Low 9 · 23.7%Moderate 7 · 18.4%High 0 · 0%

Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration

Congenital abnormalities · patients with congenital abnormalities

It is very uncertain whether embryo culture with low oxygen concentration changes congenital abnormalities compared with embryo culture with atmospheric oxygen concentration (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes abnormal uterine bleeding compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes abnormal uterine bleeding compared with megestrol (very low certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Abnormal Vaginal Bleeding or Spotting · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to higher abnormal vaginal bleeding or spotting compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

LNG‐IUS vs another combined low‐dose OCP

Uterine fibroid‐related symptoms (abnormal uterine bleeding, measured at 12 weeks, with the pictorial blood assessment chart (PBAC); lower = better) · women with uterine fibroids
2 findings from 1 review