Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Oral Health

No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

0-10 remaining teeth vs 25-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 0-10 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 2.65, 95% CI 1.84 to 3.81; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

S. mutans counts (5th-root transformed) · Adolescents/teenagers undergoing orthodontic treatment

A single study found no significant difference in S. mutans counts between aligners and fixed appliances in adolescents at 1 month (MD -2.22, 95% CI -6.82 to 2.38; ungraded).

1 finding from 1 review

Xylitol-only sugar-free chewing gum vs Pooled controls: no gum, placebo/control gum, probiotic, or fluoride varnish

Streptococcus mutans load in the oral cavity (saliva and/or dental plaque) · Adults and children (general population)

Xylitol-only sugar-free gum significantly reduced Streptococcus mutans load versus pooled controls (SMD -0.46, 95% CI -0.64 to -0.28; 12 trials, I2 43%); certainty not formally graded.

1 finding from 1 review

Fluoride-releasing resin-based bonding agent vs Non-fluoride resin-based bonding agent

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

For resin-based bonding agents, fluoride release did not significantly change WSL initiation (RR 0.97); subgroup not separately GRADE-rated.

1 finding from 1 review

Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator

Retention success rate · Children with primary molars requiring proximal (Class II) restorations

For the Rubber dam isolation: Yes subgroup, the 24-month retention success rate was 0.931 (95% CI 0.834-0.973; ungraded).

28 findings from 1 review
Show 25 more findings

Gastroesophageal or laryngopharyngeal reflux (GERD/LPR) vs Healthy individuals without reflux (controls)

Dental erosion · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)

Reflux (GERD/LPR) is associated with a higher prevalence and severity of dental erosion than in healthy individuals, but the evidence is heterogeneous, not pooled, and ungraded.

1 finding from 1 review

AG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG vs AA model: OR 1.21, 95% CI 0.88-1.65); certainty not graded.

6 findings from 1 review
Show 3 more findings

TT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of AMELX rs6639060 and dental caries susceptibility (TT vs CC model: OR 1.04, 95% CI 0.43-2.51) in the Age group: Adults subgroup; certainty not graded.

3 findings from 1 review

CT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of AMELX rs946252 and dental caries susceptibility (CT vs CC model: OR 2.80, 95% CI 0.93-8.43) in the Ethnicity: Caucasian subgroup; certainty not graded.

6 findings from 1 review
Show 3 more findings

GG genotype of LTF rs1126478 vs AA + AG genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA + AG genotype of LTF rs1126478 and dental caries susceptibility (GG vs AA + AG model: OR 0.95, 95% CI 0.80-1.13) in the Age group: Children subgroup; certainty not graded.

5 findings from 1 review
Show 2 more findings

CT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The CT genotype of AMELX rs17878486 was associated with increased dental caries risk (CT vs CC model: OR 5.11, 95% CI 1.33-19.72) in the Ethnicity: Mixed subgroup; certainty not graded.

9 findings from 1 review
Show 6 more findings