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What do systematic reviews say?

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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

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No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ sepsis (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ sepsis (within 30 days after surgery) compared with surgery alone (low certainty).

1 finding from 1 review

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ surgical complications (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ surgical complications (within 30 days… compared with surgery alone (low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review

Antibiotics vs placebo or usual care

Serious adverse events Duration 3 days to 3 weeks · acute asthma exacerbation

Antibiotics showed no clear difference in serious adverse events Duration 3 days to 3 weeks compared with placebo or usual care (low certainty).

1 finding from 1 review

Intervention not reported

Limb salvage at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention showed no clear difference in limb salvage at 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Amputation at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention showed no clear difference in amputation at 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Death at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention showed no clear difference in death at 30 days (moderate certainty).

1 finding from 1 review

Intervention not reported

Vessel patency at 30 days · patients seeking treatment for initial management of acute limb ischaemia

It is very uncertain whether the intervention changes vessel patency at 30 days (very low certainty).

1 finding from 1 review

Intervention not reported

Major haemorrhage at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention may leads to higher major haemorrhage at 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Stroke at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention showed no clear difference in stroke at 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Distal embolisation at 30 days · patients seeking treatment for initial management of acute limb ischaemia

It is very uncertain whether the intervention changes distal embolisation at 30 days (very low certainty).

1 finding from 1 review