Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years
Composite resin (hybrid 0-19.5%; bulk-fill 0-16.9%) performed comparably to or better than most alternatives across 11 RCTs; evidence is of low to unclear quality (ungraded).
1 finding from 1 review
Caries experience · European adolescents aged 15 years
Pooled caries experience was 6.62 (I² = 97.6%).
1 finding from 1 review
Sinus or fistula formation at last · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
It is very uncertain whether single-visit root canal treatment changes sinus tract or fistula formation compared with multiple-visit root canal treatment (two or more visits) (very low certainty).
1 finding from 1 review
Progression of non-cavitated enamel caries · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)
The review found no eligible studies for this question.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 18 years
Pooled caries prevalence was 0.94 (I² = 0%).
1 finding from 1 review
Adverse events · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
The review found no eligible studies for this question.
1 finding from 1 review
Diabetic complications · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age
The review found no eligible studies for this question.
1 finding from 1 review
Postoperative pain intensity in the immediate postobturation period (up to 72 hours), continuous (VAS) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
Single-visit root canal treatment showed no clear difference in postoperative pain intensity in the immediate postobturation period… compared with multiple-visit root canal treatment (two or more visits) (low certainty).
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R14 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R14 was significantly associated with ECC in the TWAS (p = 1.06e-6); genetic association, ungraded.
1 finding from 1 review
Adverse effects of treatment · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age
1 finding from 1 review
Dental caries prevalence · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
1 finding from 1 review
Milsom 2006 measured prevalence of dental caries as mean number of teeth with active caries in primary teeth (dt) and permanent teeth (DT); post-intervention changes from baseline were not significant, and the authors…
1 study · 16684 participants
GRADE not reported
Oral health-related quality of life · Children with dental caries
SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded).
1 finding from 1 review
Dental caries prevalence · European adolescents aged 18 years
Pooled caries prevalence was 0.74.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 15 years
Pooled caries prevalence was 0.50 (I² = 99.4%).
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of IGSF5 (chr21q22.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted IGSF5 expression reached the TWAS threshold for ECC (p = 7.22e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Caries experience · European adolescents aged 18 years
Pooled caries experience was 14.98 (I² = 88.0%).
1 finding from 1 review
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Caries in upper primary incisors has the lowest tooth-specific predictive value for permanent-teeth caries (RR 1.6; single study; not GRADE-rated).
1 finding from 1 review
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Early childhood caries increases the likelihood of caries in permanent teeth roughly three-fold, but the certainty of evidence is very low (OR 3.22, 95% CI 2.80 to 3.71).
1 finding from 1 review
Pain at 1 month · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
1 finding from 1 review
One study (Dhyani 2022) reported pain at 1 month: 60 teeth (all vital at enrolment, mechanical NiTi), 0 events (no participant reported pain at 1 month); no meta-analysis
1 study · 60 participants
GRADE not reported
Dental caries increment, DMFT/dmft (whole-tooth level) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
1 finding from 1 review