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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,518 questions in 135 reviews · Infectious Diseases
current versionsNo studies 135 · 8.9%Ungraded 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Blood‐feeding success (washed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 0.91 [0.74, 1.13] | NR | Low |
Intervention NR Mosquito mortality (unwashed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.25 [0.99, 1.57] | NR | Moderate |
Intervention NR Mosquito mortality (washed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.39 [0.95, 2.04] | NR | Very low |
Intervention NR Blood‐feeding success (unwashed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 0.75 [0.27, 2.11] | NR | Very low |
Intervention NR Blood‐feeding success (washed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.07 [0.49, 2.33] | NR | Low |
Intervention NR Mosquito mortality (unwashed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.2 [0.64, 2.26] | NR | Low |
Intervention NR Mosquito mortality (washed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.07 [0.92, 1.25] | NR | Low |
Intervention NR Blood‐feeding success (unwashed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 0.52 [0.12, 2.22] | NR | Very low |
Intervention NR Parasite prevalence (9‐ to 12‐month · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | OR 0.72 [0.61, 0.86] | 2 studies · 11370 participants | Moderate |
Intervention NR Blood‐feeding success (washed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.25 [0.82, 1.91] | NR | Very low |
Intervention NR Parasite prevalence (16‐ to 18‐month · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | OR 0.88 [0.74, 1.04] | 2 studies · 11822 participants | Moderate |
Intervention NR Parasite prevalence (21‐ to 25‐month · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | OR 0.79 [0.67, 0.95] | 2 studies · 10603 participants | Moderate |
Intervention NR Mosquito mortality (unwashed nets) · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.84 [1.6, 2.11] | 5 studies · 14620 participants | High |
Intervention NR Mosquito mortality (washed nets) · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.2 [0.88, 1.63] | 4 studies · 10268 participants | Very low |
Intervention NR Blood‐feeding success (unwashed nets) · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 0.6 [0.5, 0.71] | 4 studies · 14000 participants | High |
Intervention NR Blood‐feeding success (washed nets) · adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 0.81 [0.72, 0.92] | 3 studies · 9674 participants | High |
Intervention NR Mosquito mortality (unwashed nets) · Anopheles gambiae complex or Anopheles funestus group Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa (2021) · Cochrane | RR 1.68 [1.33, 2.11] | NR | Moderate |
Impact of Xpert MTB/RIF vs smear microscopy All‐cause mortality among participants · people being investigated for tuberculosis (TB) Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (2021) · Cochrane | RR 0.89 [0.75, 1.05] | 5 studies · 9932 participants | Moderate |
Impact of Xpert MTB/RIF vs smear microscopy All‐cause mortality at 6 months (subgroup) · people being investigated for tuberculosis (TB) Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (2021) · Cochrane | RR 0.98 [0.78, 1.22] | 3 studies · 8143 participants | Moderate |
Impact of Xpert MTB/RIF vs smear microscopy All‐cause mortality in people who were HIV‐positive (subgroup) · people being investigated for tuberculosis (TB) Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (2021) · Cochrane | OR 0.8 [0.67, 0.96] | 5 studies · 5855 participants | Moderate |
Impact of Xpert MTB/RIF vs smear microscopy Successful treatment outcome in participants treated for tuberculosis · people being investigated for tuberculosis (TB) Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (2021) · Cochrane | OR 1.1 [0.95, 1.26] | 3 studies · 4802 participants | Moderate |
Impact of Xpert MTB/RIF vs smear microscopy Proportion of participants who were treated for tuberculosis · people being investigated for tuberculosis (TB) Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (2021) · Cochrane | RR 1.1 [0.98, 1.23] | 5 studies · 8793 participants | Moderate |
Impact of Xpert MTB/RIF vs smear microscopy Pre‐treatment loss to · people being investigated for tuberculosis (TB) Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (2021) · Cochrane | RR 0.59 [0.41, 0.85] | 3 studies · 1217 participants | Moderate |
Impact of Xpert MTB/RIF vs smear microscopy Treated participants with bacteriological confirmation of tuberculosis · people being investigated for tuberculosis (TB) Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (2021) · Cochrane | RR 1.44 [1.29, 1.61] | 6 studies · 2068 participants | Moderate |
Ivermectin vs control Incidence of clinical malaria · adults and children living in malaria‐endemic areas Ivermectin treatment in humans for reducing malaria transmission (2021) · Cochrane | no estimate extracted | 590 participants | Very low |
Ivermectin vs control Adverse events · adults and children living in malaria‐endemic areas Ivermectin treatment in humans for reducing malaria transmission (2021) · Cochrane | RR 1.63 [1, 2.67] | 2712 participants | Very low |
Rapid susceptibility methods vs standard methods versus placebo Mortality · people with bloodstream infections Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection (2021) · Cochrane | RR 1.1 [0.82, 1.46] | 6 studies · 1638 participants | Low |
Rapid susceptibility methods vs standard methods versus placebo Mortality (subgroup genotypic) · people with bloodstream infections Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection (2021) · Cochrane | RR 1.02 [0.69, 1.49] | 4 studies · 1074 participants | Low |
Rapid susceptibility methods vs standard methods versus placebo Mortality (subgroup phenotypic) · people with bloodstream infections Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection (2021) · Cochrane | RR 1.37 [0.8, 2.35] | 2 studies · 564 participants | Low |
Rapid susceptibility methods vs standard methods versus placebo Mortality (with stewardship) · people with bloodstream infections Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection (2021) · Cochrane | RR 1.17 [0.81, 1.7] | 4 studies · 1404 participants | Low |
Rapid susceptibility methods vs standard methods versus placebo Mortality (without stewardship) · people with bloodstream infections Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection (2021) · Cochrane | RR 0.89 [0.35, 2.27] | 2 studies · 234 participants | Low |
Rapid susceptibility methods vs standard methods versus placebo Time‐to‐discharge from hospital (days) · people with bloodstream infections Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection (2021) · Cochrane | no estimate extracted | 4 studies · 1165 participants | Low |
Rapid susceptibility methods vs standard methods versus placebo Time‐to‐appropriate antibiotic · people with bloodstream infections Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection (2021) · Cochrane | no estimate extracted | 5 studies · 1493 participants | Low |
Hydroxychloroquine (HCQ) vs standard care or placebo Death due to any cause · adults with mild to severe COVID‐19 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 1.09 [0.99, 1.19] | 9 studies · 8208 participants | High |
Hydroxychloroquine (HCQ) vs placebo Participants with any adverse events · people who have been exposed to SARS‐CoV‐2 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 2.39 [1.83, 3.11] | 1 study · 700 participants | Moderate |
Hydroxychloroquine (HCQ) vs placebo Participants with serious adverse events · people who have been exposed to SARS‐CoV‐2 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | no estimate extracted | 1 study · 700 participants | Low |
Hydroxychloroquine (HCQ) vs standard care or placebo Negative PCR for SARS‐CoV‐2 on respiratory samples at day 14 from enrolmentd · adults with mild to severe COVID‐19 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 1 [0.91, 1.1] | 3 studies · 213 participants | Low |
Hydroxychloroquine (HCQ) vs standard care or placebo Progression to mechanical ventilation · adults with mild to severe COVID‐19 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 1.11 [0.91, 1.37] | 3 studies · 4521 participants | Moderate |
Hydroxychloroquine (HCQ) vs standard care or placebo Time to clinical improvement · adults with mild to severe COVID‐19 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | HR 1.01 [0.59, 1.74] | 1 study · 119 participants | Very low |
Hydroxychloroquine (HCQ) vs standard care or placebo Participants with any adverse events · adults with mild to severe COVID‐19 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 2.9 [1.49, 5.64] | 6 studies · 1394 participants | Moderate |
Hydroxychloroquine (HCQ) vs standard care or placebo Participants with serious adverse events · adults with mild to severe COVID‐19 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 0.82 [0.37, 1.79] | 6 studies · 1004 participants | Low |
Hydroxychloroquine (HCQ) vs standard care or placebo Participants with prolongation of QT‐interval on ECG · adults with mild to severe COVID‐19 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 8.47 [1.14, 63.03] | 1 study · 147 participants | Very low |
Hydroxychloroquine (HCQ) vs placebo Development of confirmed COVID‐19 at 14 days from enrolment · people who have been exposed to SARS‐CoV‐2 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 1.2 [0.5, 2.87] | 1 study · 821 participants | Very low |
Hydroxychloroquine (HCQ) vs placebo Hospitalized due to COVID‐19c · people who have been exposed to SARS‐CoV‐2 Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 (2021) · Cochrane | RR 0.98 [0.06, 15.66] | 1 study · 821 participants | Very low |
Intervention NR Index test · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for… Screening tests for active pulmonary tuberculosis in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Specificities 99% and 100% · children evaluated in inpatient or outpatient settings Index tests: Xpert MTB/RIF Role: an initial test Threshold for… Screening tests for active pulmonary tuberculosis in children (2021) · Cochrane | no estimate extracted | 2 studies · 771 participants | Moderate |
Intervention NR ≥ 1 of cough, fever, or poor weight gain · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for… Screening tests for active pulmonary tuberculosis in children (2021) · Cochrane | no estimate extracted | 4 studies · 113 participants | Low |
Intervention NR ≥ 1 of cough, fever, or decreased playfulness · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for… Screening tests for active pulmonary tuberculosis in children (2021) · Cochrane | no estimate extracted | 3 studies · 106 participants | Moderate |
Intervention NR ≥ 1 of cough, fever, poor weight gain, or tuberculosis close contact (WHO 4‐symptom symptom screen) · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for… Screening tests for active pulmonary tuberculosis in children (2021) · Cochrane | no estimate extracted | 2 studies · 1219 participants | Moderate |
Intervention NR Estimation (95% Cl) · children with close tuberculosis contacts Index test: abnormal chest radiography Role: an initial test Threshold for… Screening tests for active pulmonary tuberculosis in children (2021) · Cochrane | no estimate extracted | NR | No studies |