Cochrane · systematic review · CD012776
Piperonyl butoxide (PBO) combined with pyrethroids in insecticide‐treated nets to prevent malaria in Africa
Gleave, K, Lissenden, N, Chaplin, M, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
20
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 25%Low 5 · 25%Moderate 6 · 30%High 4 · 20%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsSummary of findings table 1
Population: adults and childen living in malaria‐endemic areas, Anopheles gambiae complex or Anopheles funestus group
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasite prevalence (4‐ to 6‐month | OR 0.74 [0.62, 0.89] | 2 studies · 11582 participants | High |
Parasite prevalence (9‐ to 12‐month | OR 0.72 [0.61, 0.86] | 2 studies · 11370 participants | Moderate Downgraded: imprecision, inconsistency |
Parasite prevalence (16‐ to 18‐month | OR 0.88 [0.74, 1.04] | 2 studies · 11822 participants | Moderate Downgraded: imprecision, inconsistency |
Parasite prevalence (21‐ to 25‐month | OR 0.79 [0.67, 0.95] | 2 studies · 10603 participants | Moderate Downgraded: imprecision, inconsistency |
Mosquito mortality (unwashed nets) | RR 1.84 [1.6, 2.11] | 5 studies · 14620 participants | High |
Mosquito mortality (washed nets) | RR 1.2 [0.88, 1.63] | 4 studies · 10268 participants | Very low Downgraded: imprecision, inconsistency |
Blood‐feeding success (unwashed nets) | RR 0.6 [0.5, 0.71] | 4 studies · 14000 participants | High |
Blood‐feeding success (washed nets) | RR 0.81 [0.72, 0.92] | 3 studies · 9674 participants | High |
Summary of findings table 2
Population: Anopheles gambiae complex or Anopheles funestus group
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mosquito mortality (unwashed nets) | RR 1.68 [1.33, 2.11] | NR | Moderate Downgraded: imprecision, inconsistency, indirectness |
Mosquito mortality (washed nets) | RR 1.07 [0.74, 1.54] | NR | Low Downgraded: imprecision, inconsistency, indirectness |
Blood‐feeding success (unwashed nets) | RR 0.9 [0.72, 1.11] | NR | Moderate Downgraded: imprecision, inconsistency, indirectness |
Blood‐feeding success (washed nets) | RR 0.91 [0.74, 1.13] | NR | Low Downgraded: imprecision, inconsistency, indirectness |
Summary of findings table 3
Population: Anopheles gambiae complex or Anopheles funestus group
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mosquito mortality (unwashed nets) | RR 1.25 [0.99, 1.57] | NR | Moderate Downgraded: imprecision, inconsistency |
Mosquito mortality (washed nets) | RR 1.39 [0.95, 2.04] | NR | Very low Downgraded: imprecision, inconsistency |
Blood‐feeding success (unwashed nets) | RR 0.75 [0.27, 2.11] | NR | Very low Downgraded: imprecision, inconsistency |
Blood‐feeding success (washed nets) | RR 1.07 [0.49, 2.33] | NR | Low Downgraded: imprecision, inconsistency |
Summary of findings table 4
Population: Anopheles gambiae complex or Anopheles funestus group
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mosquito mortality (unwashed nets) | RR 1.2 [0.64, 2.26] | NR | Low Downgraded: imprecision, inconsistency |
Mosquito mortality (washed nets) | RR 1.07 [0.92, 1.25] | NR | Low Downgraded: imprecision, inconsistency |
Blood‐feeding success (unwashed nets) | RR 0.52 [0.12, 2.22] | NR | Very low Downgraded: imprecision, inconsistency |
Blood‐feeding success (washed nets) | RR 1.25 [0.82, 1.91] | NR | Very low Downgraded: imprecision, inconsistency |