Cochrane · systematic review · CD012972
Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis
Haraka, F, Kakolwa, M, Schumacher, SG, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Impact of Xpert MTB/RIF compared to smear microscopy
Population: people being investigated for tuberculosis (TB)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality among participants Impact of Xpert MTB/RIF vs smear microscopy | RR 0.89 [0.75, 1.05] | 5 studies · 9932 participants | Moderate Downgraded: imprecision |
All‐cause mortality at 6 months (subgroup) Impact of Xpert MTB/RIF vs smear microscopy | RR 0.98 [0.78, 1.22] | 3 studies · 8143 participants | Moderate Downgraded: imprecision |
All‐cause mortality in people who were HIV‐positive (subgroup) Impact of Xpert MTB/RIF vs smear microscopy | OR 0.8 [0.67, 0.96] | 5 studies · 5855 participants | Moderate Downgraded: imprecision |
Successful treatment outcome in participants treated for tuberculosis Impact of Xpert MTB/RIF vs smear microscopy | OR 1.1 [0.95, 1.26] | 3 studies · 4802 participants | Moderate Downgraded: imprecision |
Proportion of participants who were treated for tuberculosis Impact of Xpert MTB/RIF vs smear microscopy | RR 1.1 [0.98, 1.23] | 5 studies · 8793 participants | Moderate Downgraded: imprecision |
Pre‐treatment loss to Impact of Xpert MTB/RIF vs smear microscopy | RR 0.59 [0.41, 0.85] | 3 studies · 1217 participants | Moderate Downgraded: imprecision |
Treated participants with bacteriological confirmation of tuberculosis Impact of Xpert MTB/RIF vs smear microscopy | RR 1.44 [1.29, 1.61] | 6 studies · 2068 participants | Moderate Downgraded: imprecision |