Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

334 questions · 356 findings · 30 reviews · Headline outcomes only

No studies found 133 · 37.4%GRADE not reported 9 · 2.5%Very low 102 · 28.7%Low 73 · 20.5%Moderate 36 · 10.1%High 3 · 0.8%

Primary health professional‐led or collaborative care vs specialist‐led care

Clinical recovery from severe mental disorder (immediately post intervention) Defined by BPRS decreased by ≥ 80% (RR > 1 denotes greater likelihood of recovery) · people with severe mental disorders

It is very uncertain whether primary health professional‐led or collaborative care changes clinical recovery from severe mental disorder (immediately post… compared with specialist‐led care (very low certainty).

1 finding from 1 review

Primary health professional‐led or collaborative care vs specialist‐led care

Relapse of severe mental disorder (immediately post intervention) Defined by re‐appearance of symptoms or worsening of symptoms necessitating adjustment of medicationa; Li 2002; based on 1 item scoring ≥ 5 or 2 items scoring ≥ 4 in items 4, 7, 11,... · people with severe mental disorders

It is very uncertain whether primary health professional‐led or collaborative care changes relapse of severe mental disorder (immediately post intervention)… compared with specialist‐led care (very low certainty).

1 finding from 1 review

Primary health professional‐led or collaborative care vs specialist‐led care

Hospital admission/re‐admission · people with severe mental disorders

It is very uncertain whether primary health professional‐led or collaborative care changes service utilisation ‐ hospital re‐admission (during intervention)… compared with specialist‐led care (very low certainty).

1 finding from 1 review

Intervention not reported

Time from start of symptoms to delivery of professional treatment (2a) Mean, median prehospital delay time from symptom onset of arrival at hospital/ED, proportion of participants presenting to the emergency department (ED) within 2, 3, and 4.5 hours · Adults (and/or family members) with potential for acute life‐threatening illness
1 finding from 1 review