Topical antibiotics vs placebo/no treatment
Hearing · patients with mucopurulent otorrhoea
1 finding from 1 review
- no estimate extracted1 study · 35 participantsVery low
Findings
What do systematic reviews say?
256 questions · 278 findings · 34 reviews · ENT
No studies found 86 · 30.9%GRADE not reported 1 · 0.4%Very low 88 · 31.7%Low 66 · 23.7%Moderate 35 · 12.6%High 2 · 0.7%
Topical antibiotics vs placebo/no treatment
Serious complications · patients with mucopurulent otorrhoea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Topical antibiotics vs placebo/no treatment
Suspected ototoxicity · patients with mucopurulent otorrhoea
1 finding from 1 review
- no estimate extracted1 study · 35 participantsVery low
Topical antibiotics with steroids vs placebo/no treatment
Resolution of ear discharge ‐ measured at 1 to 2 weeks · chronic suppurative otitis media
The review found no eligible studies for this question.
1 finding from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Topical antibiotics with steroids vs placebo/no treatment
Resolution of ear discharge ‐ measured after 4 weeks · chronic suppurative otitis media
1 finding from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 50 participantsVery low
Topical antibiotics with steroids vs placebo/no treatment
Health‐related quality of life · chronic suppurative otitis media
The review found no eligible studies for this question.
1 finding from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Topical antibiotics with steroids vs placebo/no treatment
Ear pain (otalgia) or discomfort or local irritation · chronic suppurative otitis media
1 finding from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 123 participantsVery low
Topical antibiotics with steroids vs placebo/no treatment
Hearing · chronic suppurative otitis media
1 finding from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 123 participantsVery low
Topical antibiotics with steroids vs placebo/no treatment
Serious complications (including intracranial complications, extracranial complications and death) · chronic suppurative otitis media
1 finding from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 173 participantsVery low
Topical antibiotics with steroids vs placebo/no treatment
Suspected ototoxicity · chronic suppurative otitis media
1 finding from 1 review
- Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 123 participantsVery low
Intranasal corticosteroids vs placebo
Disease severity as measured by patient‐reported symptom score (total nasal symptom score) · adults and children > 12 with non‐allergic rhinitis
1 finding from 1 review
- no estimate extracted4 studies · 131 participantsLow
Intranasal corticosteroids vs placebo
Significant adverse event: epistaxis · adults and children > 12 with non‐allergic rhinitis
Intranasal corticosteroids probably leads to higher significant adverse event: epistaxis compared with placebo (moderate certainty).
1 finding from 1 review
- RR 2.1 [1.24, 3.57]4 studies · 1174 participantsModerate
Intranasal corticosteroids vs placebo
Disease‐specific health‐related quality of life Short Form 12 (SF‐12v2) (range 0 to 800) · adults and children > 12 with non‐allergic rhinitis
1 finding from 1 review
- no estimate extracted1 study · 49 participantsLow
Intranasal corticosteroids vs placebo
Health outcomes Peak expiratory flow readings (higher readings indicate better peak flow) · adults and children > 12 with non‐allergic rhinitis
It is very uncertain whether intranasal corticosteroids changes objective measurement of airflow: peak flow rate (expiratory) compared with placebo (very low certainty).
1 finding from 1 review
- SMD 19802 studies · 55 participantsVery low
Intranasal corticosteroids vs placebo
Other adverse events · adults and children > 12 with non‐allergic rhinitis
Intranasal corticosteroids showed no clear difference in other adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- RR 0.99 [0.87, 1.12]3 studies · 1130 participantsModerate
Tranexamic acid vs placebo + standard care
Control of epistaxis: episodes of re‐bleeding over 10 days All treatments (topical and oral) · adults with nasal haemorrhage (epistaxis)
Tranexamic acid probably leads to lower control of epistaxis: episodes of re‐bleeding over 10 days All… compared with placebo plus usual care or usual care alone (moderate certainty).
1 finding from 1 review
- Tranexamic acid for patients with nasal haemorrhage (epistaxis) 2018 · Cochrane Headline outcomes onlyRR 0.71 [0.56, 0.9]3 studies · 225 participantsModerate
Tranexamic acid vs placebo + standard care
Control of epistaxis: episodes of re‐bleeding over 10 days Oral treatment only · adults with nasal haemorrhage (epistaxis)
Tranexamic acid probably leads to lower control of epistaxis: episodes of re‐bleeding over 10 days Oral… compared with placebo plus usual care or usual care alone (moderate certainty).
1 finding from 1 review
- Tranexamic acid for patients with nasal haemorrhage (epistaxis) 2018 · Cochrane Headline outcomes onlyRR 0.73 [0.55, 0.96]2 studies · 157 participantsModerate
Tranexamic acid vs placebo + standard care
Control of epistaxis: episodes of re‐bleeding over 10 days Topical application (10% gel) only · adults with nasal haemorrhage (epistaxis)
Tranexamic acid showed no clear difference in control of epistaxis: episodes of re‐bleeding over 10 days Topical… compared with placebo plus usual care or usual care alone (low certainty).
1 finding from 1 review
- Tranexamic acid for patients with nasal haemorrhage (epistaxis) 2018 · Cochrane Headline outcomes onlyRR 0.66 [0.41, 1.05]1 study · 68 participantsLow
Tranexamic acid vs placebo + standard care
Control of epistaxis: time to stop initial bleeding (proportion of patients whose bleeding is controlled in ≤ 30 minutes) · adults with nasal haemorrhage (epistaxis)
Tranexamic acid showed no clear difference in control of epistaxis: time to stop initial bleeding (proportion of… compared with placebo plus usual care or usual care alone (low certainty).
1 finding from 1 review
- Tranexamic acid for patients with nasal haemorrhage (epistaxis) 2018 · Cochrane Headline outcomes onlyRR 0.79 [0.56, 1.11]1 study · 68 participantsLow
Tranexamic acid vs placebo + standard care
Severity of re‐bleeding: proportion of patients requiring blood transfusion within 10 days · adults with nasal haemorrhage (epistaxis)
Tranexamic acid showed no clear difference in severity of re‐bleeding: proportion of patients requiring blood… compared with placebo plus usual care or usual care alone (low certainty).
1 finding from 1 review
- Tranexamic acid for patients with nasal haemorrhage (epistaxis) 2018 · Cochrane Headline outcomes onlyRR 0.81 [0.27, 2.48]1 study · 89 participantsLow