Cochrane · systematic review · CD013051
Topical antibiotics for chronic suppurative otitis media
Brennan‐Jones, CG, Head, K, Chong, LY, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
10
No studies
11
Included studies
NR
No studies 11 · 52.4%Ungraded 0 · 0%Very low 9 · 42.9%Low 1 · 4.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Topical antibiotics versus placebo/no treatment for chronic suppurative otitis media
Population: patients with mucopurulent otorrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge ‐ measured at 1 to 2 weeks Topical antibiotics vs placebo/no treatment | RR 6.74 [1.82, 24.99] | 1 study · 35 participants | Very low Downgraded: risk of bias, imprecision |
Resolution of ear discharge ‐ measured after 4 weeks Topical antibiotics vs placebo/no treatment | no estimate extracted | NR | No studies |
Health‐related quality of life Topical antibiotics vs placebo/no treatment | no estimate extracted | NR | No studies |
Ear pain (otalgia) or discomfort or local irritation Topical antibiotics vs placebo/no treatment | no estimate extracted | 1 study · 35 participants | Very low Downgraded: risk of bias, imprecision |
Hearing Topical antibiotics vs placebo/no treatment | no estimate extracted | 1 study · 35 participants | Very low Downgraded: risk of bias, imprecision |
Serious complications Topical antibiotics vs placebo/no treatment | no estimate extracted | NR | No studies |
Suspected ototoxicity Topical antibiotics vs placebo/no treatment | no estimate extracted | 1 study · 35 participants | Very low Downgraded: risk of bias, imprecision |
Topical antibiotics on top of systemic antibiotics for chronic suppurative otitis media
Population: CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge‐ measured at 1 to 2 weeks | RR 1.47 [1.2, 1.8] | 2 studies · 150 participants | Low Downgraded: risk of bias, imprecision |
Resolution of ear discharge ‐ measured after 4 weeks | no estimate extracted | NR | No studies |
Health‐related quality of life | no estimate extracted | NR | No studies |
Ear pain (otalgia) or discomfort or local irritation | no estimate extracted | NR | No studies |
Hearing | no estimate extracted | NR | No studies |
Serious complications | no estimate extracted | NR | No studies |
Suspected ototoxicity | no estimate extracted | 3 studies · 190 participants | Very low Downgraded: risk of bias, imprecision |
Quinolones versus aminoglycosides for chronic suppurative otitis media
Population: CSOM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge ‐ measured at 1 to 2 weeks Quinolones vs aminoglycosides | RR 1.95 [0.88, 4.29] | 6 studies · 694 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Resolution of ear discharge ‐ Measured after 4 weeks Quinolones vs aminoglycosides | no estimate extracted | NR | No studies |
Health‐related quality of life Quinolones vs aminoglycosides | no estimate extracted | NR | No studies |
Ear pain (otalgia) or discomfort or local irritation Quinolones vs aminoglycosides | no estimate extracted | 1 study · 308 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Hearing Quinolones vs aminoglycosides | no estimate extracted | 4 studies · 132 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serious complications Quinolones vs aminoglycosides | no estimate extracted | NR | No studies |
Suspected ototoxicity Quinolones vs aminoglycosides | no estimate extracted | 2 studies · 352 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |