Cochrane · systematic review · CD010592
Intranasal corticosteroids for non‐allergic rhinitis
Segboer, C, Gevorgyan, A, Avdeeva, K, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intranasal corticosteroids compared to placebo for non‐allergic rhinitis
Population: adults and children > 12 with non‐allergic rhinitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Disease severity as measured by patient‐reported symptom score (total nasal symptom score) Intranasal corticosteroids vs placebo | no estimate extracted | 4 studies · 131 participants | Low Downgraded: imprecision, publication bias |
Significant adverse event: epistaxis Intranasal corticosteroids vs placebo | RR 2.1 [1.24, 3.57] | 4 studies · 1174 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Disease‐specific health‐related quality of life Short Form 12 (SF‐12v2) (range 0 to 800) Intranasal corticosteroids vs placebo | no estimate extracted | 1 study · 49 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Objective measurement of airflow: peak flow rate (expiratory) Intranasal corticosteroids vs placebo | SMD 1980 | 2 studies · 55 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Other adverse events Intranasal corticosteroids vs placebo | RR 0.99 [0.87, 1.12] | 3 studies · 1130 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |