Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Facilitated tucking / four‐handed care / gentle human touch vs usual care

Pain (PIPP) · neonates with mechanical ventilation

Facilitated tucking / four‐handed care / gentle human touch showed no clear difference in PIPP during endotracheal suctioning Range of scale 0 to 21. Lower… compared with standard care (moderate certainty).

1 finding from 1 review

L‐arginine vs placebo

Pain 0 to 100 visual analogue scale and 10‐point Likert scale (lower score = less pain) · sickle cell disease

L‐arginine showed no clear difference in severity of pain (assessed using a 10‐cm visual analogue scale from… compared with placebo (low certainty).

1 finding from 1 review

Face‐down positioning vs other positioning

Visual acuity · people with primary macula‐involving rhegmatogenous retinal detachments

It is very uncertain whether face‐down positioning changes mean change in logMAR or Snellen visual acuity from baseline to 3… compared with other positioning (very low certainty).

1 finding from 1 review

Face‐down positioning vs other positioning

Mean objective distortion score at 3 months or later (lower is favored) · people with primary macula‐involving rhegmatogenous retinal detachments

It is very uncertain whether face‐down positioning changes mean objective distortion score at 3 months or later (lower is… compared with other positioning (very low certainty).

1 finding from 1 review

Doxycycline vs prednisolone

Quality of life (DLQI) adjusted for baseline DLQI, disease severity, age, Karnovsky score, baseline versus week 52. A lower score is more favourable. · bullous pemphigoid
1 finding from 1 review