Question · asked by 1 review
L‐arginine vs placebo: Pain 0 to 100 visual analogue scale and 10‐point Likert scale (lower score = less pain)
- Population
- sickle cell disease
- Intervention
- L‐arginine
- Comparison
- placebo
- Outcome
- Pain 0 to 100 visual analogue scale and 10‐point Likert scale (lower score = less pain)
L‐arginine showed no clear difference in severity of pain (assessed using a 10‐cm visual analogue scale from… compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
L‐arginine vs placebo Severity of pain (assessed using a 10‐cm visual analogue scale from 0 to 10; lower score is better) · sickle cell disease L‐arginine showed no clear difference in severity of pain (assessed using a 10‐cm visual analogue scale from… compared with placebo (low certainty). Antioxidant supplementation for sickle cell disease (2024) · Cochrane Headline outcomes only | no estimate extracted | 2 studies · 125 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.