Hysterectomy to control bleeding · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid showed no clear difference in surgical intervention to control bleeding: Hysterectomy compared with placebo or standard care alone (high certainty).
1 finding from 1 review
Side effects of the intervention: Any maternal vascular occlusive event · women with primary postpartum haemorrhage following vaginal or caesarean birth
Standard care plus IV tranexamic acid showed no clear difference in side effects of the intervention: Any maternal vascular occlusive… compared with placebo or standard care alone (moderate certainty).
1 finding from 1 review
Unplanned surgical intervention · incomplete miscarriage
Misoprostol may leads to higher unplanned surgical intervention compared with surgery (low certainty).
1 finding from 1 review
Unplanned surgical intervention · incomplete miscarriage
Misoprostol showed no clear difference in unplanned surgical intervention compared with expectant care (low certainty).
1 finding from 1 review
Side effects (any reported throughout the intervention period) (ALL) · pregnant women
(Maternal outcomes) Any supplements containing iron and folic acid probably leads to higher side effects (any reported throughout the intervention period) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (moderate certainty).
1 finding from 1 review
Side effects (any reported throughout the intervention period) (ALL) · pregnant women
It is very uncertain whether (Maternal outcomes) Any supplements containing iron changes side effects (any reported throughout the intervention period) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (very low certainty).
1 finding from 1 review
Use of additional medical interventions to control PPH · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to lower use of additional medical interventions to control PPH compared with placebo/no treatment (moderate certainty).
1 finding from 1 review
Participants with at least some Side Effects · Women receiving supplements in pregnancy
It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes side effects (any reported throughout intervention period) compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).
1 finding from 1 review
Adverse events associated with treatment · women during pregnancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events associated with treatment · women during pregnancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Manual removal of placenta Manual removal after intervention · women with retained placenta
It is very uncertain whether the intervention changes manual removal of placenta Manual removal after intervention (very low certainty).
1 finding from 1 review
Intervention not reported
Severe postpartum haemorrhage Objectively or subjectively measured after intervention/Estimated blood loss in ML. · women with retained placenta
It is very uncertain whether the intervention changes severe postpartum haemorrhage Objectively or subjectively measured… (very low certainty).
1 finding from 1 review
Intervention not reported
Mean blood loss Objectively or subjectively measured after intervention/Mean blood loss in ML. · women with retained placenta
1 finding from 1 review
Neural tube defects (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate leads to lower neural tube defects (All) compared with no intervention, placebo or other micronutrients without folate… (high certainty).
1 finding from 1 review
Miscarriage · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in miscarriage (All) compared with no intervention, placebo or other micronutrients without folate… (moderate certainty).
1 finding from 1 review
Cleft lip (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in cleft lip (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Cleft palate (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in cleft palate (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Congenital cardiovascular anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in congenital cardiovascular anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Other congenital anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in other congenital anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Neonatal mortality · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review