Cochrane · systematic review · CD007950
Effects and safety of periconceptional oral folate supplementation for preventing birth defects
De‐Regil, LM, Peña‐Rosas, JP, Fernández‐Gaxiola, AC, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 40%Very low 0 · 0%Low 4 · 40%Moderate 1 · 10%High 1 · 10%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Supplementation with folate versus no intervention, placebo or other micronutrients without folate (neonatal outcomes)
Population: all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neural tube defects (All) Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes) | RR 0.31 [0.17, 0.58] | 5 studies · 6708 participants | High |
Cleft lip (All) Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes) | RR 0.79 [0.14, 4.36] | 3 studies · 5612 participants | Low Downgraded: risk of bias |
Cleft palate (All) Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes) | RR 0.73 [0.05, 10.89] | 3 studies · 5612 participants | Low Downgraded: risk of bias |
Congenital cardiovascular anomalies (All) Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes) | RR 0.57 [0.24, 1.33] | 3 studies · 5612 participants | Low Downgraded: risk of bias |
Other congenital anomalies (All) Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes) | RR 0.94 [0.53, 1.66] | 3 studies · 5612 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Neonatal death Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Supplementation with folate versus no intervention, placebo or other micronutrients without folate (maternal outcomes)
Population: all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal anaemia at or near term (All) Supplementation with folate vs no intervention, placebo or other micronutrients without folate (maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Maternal red blood cell folate at or near term (All) Supplementation with folate vs no intervention, placebo or other micronutrients without folate (maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Serum folate at or near term Supplementation with folate vs no intervention, placebo or other micronutrients without folate (maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Miscarriage (All) Supplementation with folate vs no intervention, placebo or other micronutrients without folate (maternal outcomes) | RR 1.1 [0.94, 1.28] | 5 studies · 7391 participants | Moderate Downgraded: risk of bias |