Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,181 questions · 1,197 findings · 144 reviews

No studies found 196 · 16.4%GRADE not reported 213 · 17.8%Very low 274 · 22.9%Low 296 · 24.7%Moderate 171 · 14.3%High 47 · 3.9%

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs control intervention

Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder

The review found no eligible studies for this question.

1 finding from 1 review

TMP/SMX vs placebo, no treatment or non‐PCP drug

All‐cause mortality ‐ sensitivity analysis · patients with Pneumocystis pneumonia (PCP) in non‐HIV immunocompromised patients

TMP/SMX showed no clear difference in all cause mortality ‐ TMP/SMX versus placebo or no treatment compared with placebo, no treatment or non‐PCP drug (low certainty).

1 finding from 1 review

TMP/SMX vs placebo, no treatment or non‐PCP drug

Adverse events: severe adverse events requiring treatment discontinuation ‐ TMP/SMX versus placebo or no treatment Clinical and laboratory criteria and treatment discontinuations · patients with Pneumocystis pneumonia (PCP) in non‐HIV immunocompromised patients

TMP/SMX showed no clear difference in adverse events: severe adverse events requiring treatment… compared with placebo, no treatment or non‐PCP drug (moderate certainty).

1 finding from 1 review

Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment

Recurrent stroke of any type · stroke and/or TIA

Blood pressure‐lowering drugs (BPLDs) probably leads to lower recurrent stroke of any type compared with placebo or no treatment (moderate certainty).

2 findings from 1 review

Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment

Stroke, myocardial infarction, or vascular death · stroke and/or TIA

Blood pressure‐lowering drugs (BPLDs) showed no clear difference in major vascular event (composite of non‐fatal stroke, non‐fatal… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in systemic fungal infection compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review