Cochrane · systematic review · CD007858
Blood pressure‐lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack
Zonneveld, TP, Richard, E, Vergouwen, MDI, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
StrokeAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 28.6%High 5 · 71.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Blood pressure‐lowering drugs (BPLDs) compared to placebo or no treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of TIA or stroke
Population: patients with a history of TIA or stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrent stroke of any type Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment | RR 0.81 [0.7, 0.93] | 8 studies · 35110 participants | Moderate Downgraded: risk of bias |
Time to recurrent stroke Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment | HR 0.82 [0.65, 1.03] | 3 studies · 26889 participants | High |
Major vascular event (composite of non‐fatal stroke, non‐fatal myocardial infarction, or death from any vascular cause) Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment | RR 0.9 [0.78, 1.04] | 4 studies · 28630 participants | High |
Myocardial infarction Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment | RR 0.9 [0.72, 1.11] | 6 studies · 34747 participants | High |
Vascular death Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment | RR 0.85 [0.76, 0.95] | 6 studies · 34747 participants | High |
Death by any cause Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment | RR 0.98 [0.91, 1.05] | 8 studies · 35110 participants | Moderate Downgraded: risk of bias |
Dementia Blood pressure‐lowering drugs (BPLDs) vs placebo or no treatment | RR 0.88 [0.73, 1.06] | 2 studies · 6671 participants | High |