Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

747 questions · 815 findings · 144 reviews

No studies found 154 · 18.9%GRADE not reported 147 · 18%Very low 164 · 20.1%Low 199 · 24.4%Moderate 121 · 14.8%High 30 · 3.7%

Macrolides vs doxycycline

Treatment failure · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes treatment failure compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 48 hours · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review

Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo

Gastrointestinal disorders not otherwise specified · any indication

Gastrointestinal adverse events in people taking macrolide antibiotics probably leads to higher gastrointestinal disorders not otherwise specified compared with placebo (moderate certainty).

1 finding from 1 review

Macroplastique vs dextranomer/hyaluronic acid polymer (Deflux) to correct vesicoureteric reflux

Number of ureters with persistent VUR > grade 1 at 1 year · primary VUR

Macroplastique probably leads to lower number of ureters with persistent VUR > grade 1 at 1 year compared with dextranomer/hyaluronic acid polymer (Deflux) to correct… (moderate certainty).

1 finding from 1 review

Macroplastique vs dextranomer/hyaluronic acid polymer (Deflux) to correct vesicoureteric reflux

Number of kidneys with temporary renal dilatation after injection · primary VUR

Macroplastique may leads to higher number of kidneys with temporary renal dilatation after injection compared with dextranomer/hyaluronic acid polymer (Deflux) to correct… (low certainty).

1 finding from 1 review