Cochrane · systematic review · CD011825
Adverse events in people taking macrolide antibiotics versus placebo for any indication
Hansen, MP, Scott, AM, McCullough, A, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 20%Low 5 · 50%Moderate 3 · 30%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Gastrointestinal adverse events in people taking macrolide antibiotics versus placebo for any indication
Population: any indication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Gastrointestinal disorders not otherwise specified Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo | OR 2.16 [1.56, 3] | 23 studies · 3295 participants | Moderate Downgraded: imprecision |
Abdominal pain Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo | OR 1.66 [1.22, 2.26] | 23 studies · 7776 participants | Low Downgraded: imprecision |
Diarrhoea Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo | OR 1.7 [1.34, 2.16] | 37 studies · 23754 participants | Low Downgraded: imprecision |
Nausea Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo | OR 1.61 [1.37, 1.9] | 28 studies · 14983 participants | Moderate Downgraded: imprecision |
Vomiting Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo | OR 1.27 [1.04, 1.56] | 15 studies · 5328 participants | Moderate Downgraded: imprecision |
Other adverse events in people taking macrolide antibiotics versus placebo for any indication
Population: any indication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cardiac disorders Other adverse events in people taking macrolide antibiotics vs placebo | OR 0.87 [0.54, 1.4] | 7 studies · 1715 participants | Very low Downgraded: imprecision |
Hearing loss Other adverse events in people taking macrolide antibiotics vs placebo | OR 1.3 [1, 1.7] | 4 studies · 1369 participants | Low Downgraded: imprecision |
Taste disturbance Other adverse events in people taking macrolide antibiotics vs placebo | OR 4.95 [1.64, 14.93] | 5 studies · 932 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Hepatobiliary disorders Other adverse events in people taking macrolide antibiotics vs placebo | OR 1.04 [0.27, 4.09] | 4 studies · 443 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Deaths Other adverse events in people taking macrolide antibiotics vs placebo | OR 0.96 [0.87, 1.06] | 52 studies · 216246 participants | Low Downgraded: imprecision |