Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

PTFE vs Dacron

Primary patency ( · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

PTFE showed no clear difference in primary patency (24 months) compared with dacron (low certainty).

2 findings from 1 review

PTFE vs Dacron

Secondary patency (24 months) · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

PTFE may leads to higher secondary patency (24 months) compared with dacron (low certainty).

1 finding from 1 review

PTFE vs Dacron

Limb salvage · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

PTFE showed no clear difference in limb salvage (24 months) compared with dacron (low certainty).

1 finding from 1 review

Preoperative radiotherapy vs surgery

Overall mortality ‐ only total mesorectal excision ( · People with localised rectal carcinoma

Preoperative radiotherapy showed no clear difference in overall mortality ‐ only total mesorectal excision ( compared with surgery alone (low certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Bradycardia (requiring pharmacological or pacemaker treatment during the period of study drug administration) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists probably leads to higher bradycardia (requiring pharmacological or pacemaker treatment during… compared with control (moderate certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Hypotension (requiring treatment with inotropes or vasopressors during the period of study drug administration) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists showed no clear difference in hypotension (requiring treatment with inotropes or vasopressors… compared with control (low certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

All‐cause mortality rate at 30 days · adults having abdominal surgery

Epidural analgesia showed no clear difference in all‐cause mortality rate at 30 days compared with intravenous patient‐controlled analgesia (low certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

Failure of analgesic technique requiring alternative approach (assessed at any time) · adults having abdominal surgery

Epidural analgesia probably leads to higher failure of analgesic technique requiring alternative approach… compared with intravenous patient‐controlled analgesia (moderate certainty).

1 finding from 1 review

Epidural analgesia vs intravenous patient‐controlled analgesia

Adverse events (assessed at any time during · adults having abdominal surgery

Epidural analgesia showed no clear difference in adverse events (assessed at any time during compared with intravenous patient‐controlled analgesia (low certainty).

1 finding from 1 review