Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Comparison 13: SSRIs vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)

Comparison 6: SSRIs probably leads to lower treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (moderate certainty).

1 finding from 1 review

Comparison 7: TCAs vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)

Comparison 7: TCAs may leads to lower treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)

It is very uncertain whether comparison 2: Antipsychotics changes treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (very low certainty).

1 finding from 1 review

Comparison 9: NaSSAs vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)

Comparison 4: NaSSAs may leads to lower treatment efficacy ‐ Treatment response, as measured by the Global… compared with placebo (low certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Ectopic pregnancy rate per couple · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes incidence of ectopic pregnancies per couple compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate · assisted reproduction technology cycles

Glucocorticoids showed no clear difference in clinical pregnancy rate per couple –pregnancy rate per couple… compared with no glucocorticoids or placebo (low certainty).

4 findings from 1 review
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Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate per couple – subgroup IVF · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple – subgroup IVF compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review