Cochrane · systematic review · CD003870
Oxycodone for cancer‐related pain
Schmidt-Hansen, M, Bennett, MI, Arnold, S, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
14
No studies
1
Included studies
NR
No studies 1 · 6.7%Ungraded 0 · 0%Very low 9 · 60%Low 5 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsCR oxycodone compared with IR oxycodone for cancer‐related pain in adults
Population: adults with cancer‐related pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity (mean across treatment or at end of treatment; length of treatment varied across trials; various pain intensity scales; SMD) CR oxycodone vs IR oxycodone | SMD 0.12 | 3 studies · 319 participants | Very low Downgraded: risk of bias |
Constipation (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs IR oxycodone | RR 0.71 [0.45, 1.13] | 3 studies · 317 participants | Very low Downgraded: risk of bias, imprecision |
Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs IR oxycodone | RR 1.03 [0.69, 1.54] | 3 studies · 317 participants | Very low Downgraded: risk of bias, imprecision |
Nausea (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs IR oxycodone | RR 0.85 [0.56, 1.28] | 3 studies · 317 participants | Very low Downgraded: risk of bias, imprecision |
Vomiting (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs IR oxycodone | RR 0.66 [0.38, 1.15] | 3 studies · 317 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life CR oxycodone vs IR oxycodone | no estimate extracted | 3 studies · 578 participants | Low Downgraded: risk of bias |
Participant preference CR oxycodone vs IR oxycodone | no estimate extracted | NR | No studies |
CR oxycodone compared with CR morphine for cancer‐related pain in adults
Population: adults with cancer‐related pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity (various pain intensity scales; SMD) CR oxycodone vs CR morphine | SMD 0.14 [0.01, 0.27] | 7 studies · 882 participants | Low Downgraded: risk of bias |
Constipation ‐ all available data (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs CR morphine | RR 0.75 [0.66, 0.86] | 18 studies · 1894 participants | Low Downgraded: risk of bias |
Constipation ‐ only English language studies (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs CR morphine | RR 0.98 [0.82, 1.16] | 5 studies · 797 participants | Very low Downgraded: risk of bias, imprecision |
Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs CR morphine | RR 0.88 [0.74, 1.05] | 15 studies · 1486 participants | Low Downgraded: risk of bias |
Nausea (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs CR morphine | RR 0.93 [0.77, 1.12] | 13 studies · 1388 participants | Low Downgraded: risk of bias |
Vomiting (Event rate during treatment, length of treatment varied across trials) CR oxycodone vs CR morphine | RR 0.81 [0.63, 1.04] | 13 studies · 1388 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life CR oxycodone vs CR morphine | no estimate extracted | 3 studies · 149 participants | Very low Downgraded: risk of bias, imprecision |
Participant preference (end of treatment in a cross‐over trial with each phase lasting seven days) CR oxycodone vs CR morphine | no estimate extracted | 1 study · 23 participants | Very low Downgraded: risk of bias, imprecision |