Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

Adverse events due to periodontal therapy · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review

Single component intervention vs control

Adherence to pharmacotherapy: number of people completing treatment · COPD

Single component intervention showed no clear difference in adherence to pharmacotherapy: number of people completing treatment compared with control (low certainty).

1 finding from 1 review

Multi‐component intervention vs control

Adherence to pharmacotherapy: number of people achieving adherence to medication · COPD

Multi‐component intervention may leads to higher adherence to pharmacotherapy: number of people achieving adherence… compared with control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Enteral tube feeding vs intravenous fluids

Change in modality of fluid therapy · health problem or population

Summary of findings table ‐ Enteral tube feeding probably leads to lower change in modality of fluid therapy compared with intravenous fluids (moderate certainty).

1 finding from 1 review

Family therapy vs placebo

Repetition of SH at post‐intervention · self‐harm in children and adolescents (up to 18 years or age)

Comparison 7: Family therapy showed no clear difference in repetition of SH at post‐intervention compared with placebo (moderate certainty).

1 finding from 1 review

Nicotine replacement therapy vs control

Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) · Pregnant women who smoke

Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

1 finding from 1 review

Regimens containing quinolone vs regimens containing cephalosporin

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing quinolone changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporins (very low certainty).

1 finding from 1 review

Regimens containing nitroimidazole vs no nitroimidazole

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

Regimens containing nitroimidazole showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with no nitroimidazole (low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing quinolone

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing quinolone (very low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing cephalosporin

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporin (very low certainty).

1 finding from 1 review

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review

Alteplase vs urokinase

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

Alteplase showed no clear difference in overall treatment failure, including mortality, thoracic surgery or… compared with urokinase (low certainty).

1 finding from 1 review

Fibrinolytics vs placebo

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

It is very uncertain whether fibrinolytics changes overall treatment failure, including mortality, thoracic surgery or… compared with placebo (very low certainty).

1 finding from 1 review

Streptokinase vs urokinase

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

Streptokinase showed no clear difference in overall treatment failure, including mortality, thoracic surgery or… compared with urokinase (low certainty).

1 finding from 1 review

Intervention not reported

Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 5‐ to 6‐year · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).

1 finding from 1 review

Intervention not reported

Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 12 year · people with glioma surviving at least two years

It is very uncertain whether the intervention changes intervention: radiotherapy Comparison: no adjuvant treatment… (very low certainty).

1 finding from 1 review