Cochrane · systematic review · CD013047
Long‐term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma
Lawrie, TA, Gillespie, D, Dowswell, T, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 62.5%Low 3 · 37.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: people with glioma surviving at least two years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 5‐ to 6‐year | RR 1.38 [0.92, 2.06] | 1 study · 195 participants | Very low Downgraded: imprecision |
Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 12 year | RR 1.95 [1.02, 3.71] | 1 study · 65 participants | Very low Downgraded: imprecision |
Intervention: radiotherapy Comparison: no adjuvant treatment Outcome: neurocognitive impairment at 2 year | RR 2.5 [0.11, 56.98] | 1 study · 31 participants | Very low Downgraded: imprecision |
Intervention: radiotherapy Comparison: chemotherapy Outcome: neurocognitive impairment at 3 year | RR 1.43 [0.36, 5.7] | 1 study · 117 participants | Low Downgraded: imprecision |
Intervention: high‐dose radiotherapy Comparison: low‐dose radiotherapy Outcome: neurocognitive impairment at 2 years after treatment | RR 0.53 [0.06, 4.85] | 1 study · 65 participants | Very low Downgraded: imprecision |
Intervention: high‐dose radiotherapy Comparison: low‐dose radiotherapy Outcome: neurocognitive impairment at 5 years after treatment | RR 0.16 [0.01, 3.2] | 1 study · 38 participants | Very low Downgraded: imprecision |
Intervention: chemoradiotherapy Comparison: radiotherapy Outcome: neurocognitive impairment at 3 years after treatment | RR 0.37 [0.02, 8.88] | 1 study · 91 participants | Low Downgraded: imprecision |
Intervention: stereotactic conformal radiotherapy Comparison: radiotherapy Outcome: neurocognitive impairment at 5 years after treatment | RR 4.62 [0.25, 86.72] | 1 study · 23 participants | Low Downgraded: imprecision |