Cochrane · systematic review · CD010078
Pharmacological interventions for promoting smoking cessation during pregnancy
Claire, R, Chamberlain, C, Davey, MA, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Tobacco AddictionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nicotine replacement therapy compared to control for smoking cessation during pregnancy
Population: pregnant women who smoke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) Nicotine replacement therapy vs control | RR 1.37 [1.08, 1.74] | 9 studies · 2336 participants | Low Downgraded: risk of bias, imprecision |
Mean birthweight (g) Nicotine replacement therapy vs control | MD 99.73 | 7 studies · 2202 participants | Low Downgraded: imprecision, inconsistency |
Miscarriage and spontaneous abortion Nicotine replacement therapy vs control | RR 1.6 [0.53, 4.83] | 5 studies · 1916 participants | Low Downgraded: imprecision |
Bupropion compared to control for smoking cessation during pregnancy
Population: pregnant women who smoke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Biochemically validated smoking cessation at the latest point in pregnancy (20 weeks' gestation or more) Bupropion vs control | RR 0.74 [0.21, 2.64] | 2 studies · 76 participants | Low Downgraded: imprecision |
Mean birthweight (g) Bupropion vs control | MD 122.64 | 2 studies · 68 participants | Low Downgraded: imprecision |
Miscarriage and spontaneous abortion Bupropion vs control | no estimate extracted | NR | No studies |