Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Ergot alkaloids (any route of administration) vs no uterotonic agents

Pain after birth requiring analgesia (not prespecified) · women in the third stage of labour

Ergot alkaloids (any route of administration) probably leads to higher pain after birth requiring analgesia (not prespecified) compared with no uterotonic agents (moderate certainty).

1 finding from 1 review

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Maternal blood loss of 500 mL or greater · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to lower estimated or measured blood loss of at least 500 mL visual estimation compared with no uterotonic agents (low certainty).

1 finding from 1 review

IM pethidine vs placebo

Maternal satisfaction with analgesia measured during labour (number of women satisfied or very satisfied after 30 minutes) · women in labour

It is very uncertain whether IM pethidine changes maternal satisfaction with analgesia measured during labour (number… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Maternal satisfaction with analgesia (Analgesic effect described as satisfactory (not clear when measured))
1 finding from 1 review

Intervention not reported

Maternal pain score or pain measured in labour (Pain intensity 4 or 5 on 5‐point scale (1 hour))
1 finding from 1 review