Cochrane · systematic review · CD005456
Prophylactic use of ergot alkaloids in the third stage of labour
Liabsuetrakul, T, Choobun, T, Peeyananjarassri, K, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
18
No studies
3
Included studies
NR
No studies 3 · 14.3%Ungraded 0 · 0%Very low 1 · 4.8%Low 11 · 52.4%Moderate 6 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ergot alkaloids (any route of administration) versus no uterotonic agents in the third stage of labour
Population: women in the third stage of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean blood loss (mL) visual estimation Ergot alkaloids (any route of administration) vs no uterotonic agents | no estimate extracted | 3 studies · 2718 participants | Moderate Downgraded: risk of bias |
PPH (estimated or measured blood loss of at least 500 mL) visual estimation Ergot alkaloids (any route of administration) vs no uterotonic agents | RR 0.52 [0.28, 0.94] | 5 studies · 3708 participants | Low Downgraded: risk of bias |
Severe PPH (estimated or measured blood loss of at least 1000 mL) visual estimation Ergot alkaloids (any route of administration) vs no uterotonic agents | RR 0.32 [0.04, 2.59] | 2 studies · 1718 participants | Very low Downgraded: risk of bias |
Maternal haemoglobin concentration at 24 to 48 hours postpartum (g/dL) Ergot alkaloids (any route of administration) vs no uterotonic agents | no estimate extracted | 1 study · 1429 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Use of therapeutic uterotonics Ergot alkaloids (any route of administration) vs no uterotonic agents | RR 0.37 [0.15, 0.9] | 3 studies · 2698 participants | Low Downgraded: risk of bias |
Elevation of blood pressure Ergot alkaloids (any route of administration) vs no uterotonic agents | RR 2.6 [1.03, 6.57] | 3 studies · 2559 participants | Low Downgraded: risk of bias |
Pain after birth requiring analgesia (not prespecified) Ergot alkaloids (any route of administration) vs no uterotonic agents | RR 2.53 [1.34, 4.78] | 1 study · 1429 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Intravenous/intramuscular ergot alkaloids versus no uterotonic agents in the third stage of labour
Population: women in the third stage of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean blood loss (mL) visual estimation Intravenous/intramuscular ergot alkaloids vs no uterotonic agents | no estimate extracted | 2 studies · 2429 participants | Moderate Downgraded: risk of bias |
Estimated or measured blood loss of at least 500 mL visual estimation Intravenous/intramuscular ergot alkaloids vs no uterotonic agents | RR 0.41 [0.22, 0.75] | 4 studies · 3419 participants | Low Downgraded: risk of bias |
Estimated or measured blood loss of at least 1000 mL visual estimation Intravenous/intramuscular ergot alkaloids vs no uterotonic agents | RR 0.09 [0.01, 0.72] | 1 study · 1429 participants | Low Downgraded: risk of bias |
Maternal haemoglobin concentration at 24 to 48 hours postpartum (g/dL) Intravenous/intramuscular ergot alkaloids vs no uterotonic agents | no estimate extracted | 1 study · 1429 participants | Moderate Downgraded: risk of bias |
Use of therapeutic uterotonics Intravenous/intramuscular ergot alkaloids vs no uterotonic agents | RR 0.25 [0.1, 0.66] | 2 studies · 2409 participants | Low Downgraded: risk of bias |
Elevation of blood pressure Intravenous/intramuscular ergot alkaloids vs no uterotonic agents | RR 2.6 [1.03, 6.57] | 3 studies · 2559 participants | Low Downgraded: risk of bias |
Pain after birth requiring analgesia (not prespecified) Intravenous/intramuscular ergot alkaloids vs no uterotonic agents | RR 2.53 [1.34, 4.78] | 1 study · 1429 participants | Moderate Downgraded: risk of bias |
Oral ergot alkaloids versus no uterotonic agents in the third stage of labour
Population: women in the third stage of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean blood loss (mL) visual estimation Oral ergot alkaloids vs no uterotonic agents | no estimate extracted | 1 study · 289 participants | Low Downgraded: imprecision |
Estimated or measured blood loss of at least 500 mL visual estimation Oral ergot alkaloids vs no uterotonic agents | RR 0.96 [0.72, 1.29] | 1 study · 289 participants | Low Downgraded: imprecision |
Estimated or measured blood loss of at least 1000 mL visual estimation Oral ergot alkaloids vs no uterotonic agents | RR 0.73 [0.36, 1.5] | 1 study · 289 participants | Low Downgraded: imprecision |
Maternal haemoglobin concentration at 24 to 48 hours postpartum (g/dL) Oral ergot alkaloids vs no uterotonic agents | no estimate extracted | NR | No studies |
Use of therapeutic uterotonics Oral ergot alkaloids vs no uterotonic agents | RR 0.79 [0.47, 1.34] | 1 study · 289 participants | Low Downgraded: imprecision |
Elevation of blood pressure Oral ergot alkaloids vs no uterotonic agents | no estimate extracted | NR | No studies |
Pain after birth requiring analgesia (not prespecified) Oral ergot alkaloids vs no uterotonic agents | no estimate extracted | NR | No studies |