Pregabalin leads to higher withdrawal due to adverse events compared with placebo at end of treatment (high certainty).
Pregabalin showed no clear difference in serious adverse events compared with placebo at end of treatment (moderate certainty).
Pregabalin leads to higher dizziness reported to be an adverse event compared with placebo at end of treatment (high certainty).
Radioisotopes probably leads to higher pain relief ‐ Complete relief compared with placebo (moderate certainty).
Radioisotopes probably leads to higher pain relief ‐ Complete/Partial relief compared with placebo (moderate certainty).
Radioisotopes showed no clear difference in compression of spinal cord compared with placebo (low certainty).
Radioisotopes showed no clear difference in pain flares compared with placebo (low certainty).
Radioisotopes showed no clear difference in thrombocytopenia III‐IV compared with placebo (low certainty).
Radioisotopes may leads to higher leucocytopenia III‐IV compared with placebo (low certainty).
Methylnaltrexone probably leads to higher rescue free laxation within 4 hours compared with placebo (moderate certainty).
Methylnaltrexone probably leads to higher rescue free laxation within 24 hours compared with placebo (moderate certainty).
It is very uncertain whether the intervention changes complete pain relief (very low certainty).
It is very uncertain whether the intervention changes less or equal analgesia consumption (very low certainty).
It is very uncertain whether the intervention changes adverse effects (very low certainty).