Question · asked by 1 review
Methylnaltrexone vs placebo: Rescue free laxation within 4 hours
- Population
- patients with the management of opioid‐induced constipation in palliative care patients
- Intervention
- Methylnaltrexone
- Comparison
- placebo
- Outcome
- Rescue free laxation within 4 hours
Methylnaltrexone probably leads to higher rescue free laxation within 4 hours compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Methylnaltrexone vs placebo Rescue free laxation within 4 hours · patients with the management of opioid‐induced constipation in palliative care patients Methylnaltrexone probably leads to higher rescue free laxation within 4 hours compared with placebo (moderate certainty). Laxatives or methylnaltrexone for the management of constipation in palliative care patients (2011) · Cochrane Headline outcomes only | OR 6.95 [3.83, 12.61] | 2 studies · 287 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Laxatives or methylnaltrexone for the management of constipation in palliative care patients 2011 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.