Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Adenoidectomy and ventilation tubes vs watchful waiting

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and ventilation tubes changes presence/persistence of OME (at 2 years ‐ long‐term) № of… compared with no treatment/watchful waiting (very low certainty).

1 finding from 1 review

Adenoidectomy (with or without myringotomy) vs watchful waiting

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy (with or without myringotomy) changes presence or persistence of OME ‐ over 12 months № of participants:… compared with no treatment/watchful waiting (very low certainty).

1 finding from 1 review

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and bilateral ventilation tubes changes presence/persistence of OME ‐ over 12 months № of participants: 254… compared with bilateral ventilation tubes only (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether antibiotics changes presence/persistence of OME compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs no treatment

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

Antibiotics may leads to lower presence/persistence of OME (up to 3 months) № of participants: 542… compared with no treatment (low certainty).

1 finding from 1 review

Intranasal steroid spray vs no treatment

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether topical (intranasal) steroids changes presence/persistence of OME (short‐term); assumed ICC = 0.5 compared with no treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Transfer to inpatient care Defined as referral for: presence of danger signs and failed appetite test on first day of treatment (Alvarez Moran 2018)b; appearance of severe signs of illness, persistent oedema, absence of weight gain in non‐oedemato... · children aged > 6 months and < 5 years with wasting

It is very uncertain whether the intervention changes transfer to inpatient care Defined as referral for: presence of… (very low certainty).

1 finding from 1 review

Summary of findings. Peer reviewer training vs standard journal practice or no training

Stakeholders' assessment of review quality (change score) Assessed using either:A) a 5‐point scale, change scores range from −4 to 4 (3 studies);B) a 5‐point scale, expressed by "slope of quality score change"(1 study); orC) the MQAI, from −144 to... · peer reviewers
1 finding from 1 review

Sodium fluoride (NaF) varnish, applied every 3 months, plus OHI vs inactive control

Root carious lesions prevention · Older adults with root caries (community-dwelling or residential elders)

In elders, sodium fluoride varnish gave a 64% prevented fraction for root caries vs water, lower than SDF (71%) (p<0.01; ungraded).

1 finding from 1 review

Strategies to integrate oral health into primary care (e.g., training/education of non-dental primary care professionals, policy/financing and health-insurance changes, colocation of dental and medical services, interprofessional and community-health-worker collaboration, teledentistry, integrated oral health assessment tools, school-based activities) vs No integration / usual care (or pre-integration baseline; many included studies uncontrolled)

Barriers and facilitators to implementation of the integration strategy (qualitative) · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…

Key barriers to implementing integration strategies were time/staff/resource constraints and lack of organisational support, while facilitators were professionals' knowledge and attitudes and supportive governance/leadership (qualitative; ungraded).

1 finding from 1 review
  • Strategies to integrate oral health into primary care: a systematic review. 2023 All outcomes
    Primary care, community, school, and aged-care/residential/nursing-home settings
    The most commonly studied qualitative outcomes were barriers and facilitators related to the strategy implementation process. Reported barriers were time and staff constraints, resource limitations and lack of…
    15 studies
    GRADE not reported

Periodontal disease (periodontitis; clinical attachment loss >=4 mm) vs Adults without periodontal disease (healthy periodontal status; CAL <=3 mm)

Root caries (presence of root caries) · Adults (mean age ~53 years)

Adults with periodontal disease had significantly higher odds of root caries than those without (pooled OR 1.38, 95% CI 1.25 to 1.53; 2 observational studies; low certainty).

1 finding from 1 review

38% SDF (one-time application) vs Information unavailable

New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars

One-time 38% SDF gave a 57% prevented fraction for caries in children's permanent first molars (single study; ungraded).

1 finding from 1 review

Strategies to integrate oral health into primary care (e.g., training/education of non-dental primary care professionals, policy/financing and health-insurance changes, colocation of dental and medical services, interprofessional and community-health-worker collaboration, teledentistry, integrated oral health assessment tools, school-based activities) vs No integration / usual care (or pre-integration baseline; many included studies uncontrolled)

Oral disease outcomes, including dental caries estimates · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…

Most studies reported improved oral disease outcomes with integration strategies (8 of 9 studies improved, 1 no change; 9 studies, narrative synthesis; ungraded).

1 finding from 1 review
  • Strategies to integrate oral health into primary care: a systematic review. 2023 All outcomes
    Primary care, community, school, and aged-care/residential/nursing-home settings
    Nine studies reported oral disease outcomes, seven of which measured change in dental caries estimates. Eight of the nine studies reported improved oral disease outcomes; one (Vichayanrat 2012) reported no change in…
    9 studies
    GRADE not reported

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Dental caries prevalence and severity · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in dental caries/severity between ART regimens (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in linear gingival erythema between CLWH with and without ART (very low certainty).

1 finding from 1 review