Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Any antihypertensive drug vs no antihypertensive drugs/placebo

Elective delivery (induction of labour + elective caesarean section) · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in elective delivery (induction of labour + elective caesarean section) compared with no antihypertensive drugs/placebo (moderate certainty).

1 finding from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Fetal/neonatal/infant · women with mild to moderate hypertension during pregnancy

The review found no eligible studies for this question.

2 findings from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Admission to neonatal or intensive care nursery · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in admission to neonatal or intensive care nursery compared with no antihypertensive drugs/placebo (low certainty).

1 finding from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Total reported fetal or neonatal deaths (including miscarriage) · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in total reported fetal or neonatal deaths (including miscarriage) compared with no antihypertensive drugs/placebo (moderate certainty).

1 finding from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Small‐for‐gestational age · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in small‐for‐gestational age compared with no antihypertensive drugs/placebo (moderate certainty).

1 finding from 1 review

Interventionist care vs expectant care

Intraventricular haemorrhage or hypoxic ischaemic encephalopathy · women with severe pre‐eclampsia between 24 and 34 weeks' gestation

Interventionist care probably leads to higher intraventricular haemorrhage or hypoxic ischaemic encephalopathy compared with expectant (delayed delivery) care (moderate certainty).

1 finding from 1 review

Intervention not reported

Preterm birth < 37 weeks · pregnant women and their babies

The intervention leads to lower preterm birth < 37 weeks (high certainty).

1 finding from 1 review

Intervention not reported

Pre‐eclampsia · pregnant women

The intervention showed no clear difference in pre‐eclampsia (low certainty).

1 finding from 1 review

Intervention not reported

Gestational length · pregnant women

The intervention probably leads to higher gestational length (moderate certainty).

1 finding from 1 review

Intervention not reported

Maternal serious adverse events · pregnant women

The intervention showed no clear difference in maternal serious adverse events (low certainty).

1 finding from 1 review