Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

178 questions · 178 findings · 7 reviews · Headline outcomes only

No studies found 1 · 0.6%GRADE not reported 44 · 24.7%Very low 16 · 9%Low 14 · 7.9%Moderate 100 · 56.2%High 3 · 1.7%

Paroxetine vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether paroxetine changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Paroxetine vs placebo

Secondary outcome: acceptability of treatment · people with anxiety and comorbid alcohol use disorders

It is very uncertain whether paroxetine changes treatment acceptability compared with placebo (very low certainty).

1 finding from 1 review