Cochrane · systematic review · CD013674
New generation antidepressants for depression in children and adolescents: a network meta‐analysis
Hetrick, SE, McKenzie, JE, Bailey, AP, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
121
current version
GRADE rated
121
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 62 · 51.2%Low 36 · 29.8%Moderate 20 · 16.5%High 3 · 2.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table comparing individual antidepressants on clinician‐rated depression symptoms (CDSR‐R)
Population: children and/or adolescents with depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
fluoxetine:desvenlafaxine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
fluoxetine:duloxetine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
fluoxetine:vilazodone | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
fluoxetine:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
citalopram:desvenlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
duloxetine:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
escitalopram:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
fluoxetine:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
mirtazapine:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
citalopram:paroxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
sertraline:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
citalopram:venlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
citalopram:vilazodone | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
citalopram:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
duloxetine:desvenlafaxine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
escitalopram:desvenlafaxine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
mirtazapine:desvenlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
paroxetine:desvenlafaxine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
sertraline:desvenlafaxine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
venlafaxine:desvenlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
vilazodone:desvenlafaxine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
desvenlafaxine:vortioxetine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
duloxetine: escitalopram | no estimate extracted | NR | High |
duloxetine:mirtazapine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
duloxetine:paroxetine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
sertraline:duloxetine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
duloxetine:venlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
duloxetine:vilazodone | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
duloxetine:vortioxetine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
fluoxetine:escitalopram | no estimate extracted | NR | High |
escitalopram:mirtazapine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
escitalopram:paroxetine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
sertraline:escitalopram | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
escitalopram:venlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
escitalopram:vilazodone | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
escitalopram:vortioxetine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
fluoxetine:mirtazapine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
fluoxetine:paroxetine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
sertraline:fluoxetine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
fluoxetine:venlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
mirtazapine:paroxetine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
sertraline:mirtazapine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
mirtazapine:venlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
mirtazapine:vilazodone | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
mirtazapine:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
sertraline:paroxetine | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
venlafaxine:paroxetine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
paroxetine:vilazodone | no estimate extracted | NR | High |
paroxetine:vortioxetine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
sertraline:venlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
sertraline:vilazodone | no estimate extracted | NR | Moderate Downgraded: risk of bias, inconsistency, indirectness |
sertraline:vortioxetine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
venlafaxine:vilazodone | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
venlafaxine:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, inconsistency, indirectness |
vilazodone:vortioxetine | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency, indirectness |
Summary of findings table comparing individual antidepressants on suicidal behaviour
Population: children and/or adolescents with depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
desvenlafaxine:fluoxetine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
duloxetine:fluoxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vilazodone:fluoxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
fluoxetine:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
desvenlafaxine:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
duloxetine:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
escitalopram:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
fluoxetine:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
mirtazapine:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
citalopram:paroxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
citalopram:sertraline | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
citalopram:venlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vilazodone:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vortioxetine:citalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
desvenlafaxine:duloxetine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
escitalopram:desvenlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
mirtazapine:desvenlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
desvenlafaxine:paroxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
desvenlafaxine:sertraline | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
desvenlafaxine:venlafaxine | no estimate extracted | NR | Moderate Downgraded: risk of bias, indirectness |
desvenlafaxine:vilazodone | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
desvenlafaxine:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
escitalopram:duloxetine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
mirtazapine:duloxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
duloxetine:paroxetine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
duloxetine:sertraline | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
duloxetine:venlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
vilazodone:duloxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
duloxetine:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
escitalopram:fluoxetine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
mirtazapine:escitalopram | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
escitalopram:paroxetine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
escitalopram:sertraline | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
escitalopram:venlafaxine | no estimate extracted | NR | Moderate Downgraded: risk of bias, indirectness |
escitalopram:vilazodone | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
escitalopram:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
mirtazapine:fluoxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
fluoxetine:paroxetine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
fluoxetine:sertraline | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
fluoxetine:venlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
mirtazapine:paroxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
mirtazapine:sertraline | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
mirtazapine:venlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
mirtazapine:vilazodone | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
mirtazapine:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
paroxetine:sertraline | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
paroxetine:venlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vilazodone:paroxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vortioxetine:paroxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
sertraline:venlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vilazodone:sertraline | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vortioxetine:sertraline | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vilazodone:venlafaxine | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
vortioxetine:venlafaxine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vilazodone:vortioxetine | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
citalopram:placebo | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
desvenlafaxine:placebo | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
duloxetine:placebo | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
escitalopram:placebo | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
fluoxetine:placebo | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
mirtazapine:placebo | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
paroxetine:placebo | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
sertraline:placebo | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
venlafaxine:placebo | no estimate extracted | NR | Low Downgraded: risk of bias, indirectness |
vilazodone:placebo | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |
vortioxetine:placebo | no estimate extracted | NR | Very low Downgraded: risk of bias, indirectness |