Cochrane · systematic review · CD007505
Pharmacotherapy for anxiety and comorbid alcohol use disorders
Ipser, JC, Wilson, D, Akindipe, TO, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 6 · 85.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Paroxetine compared with placebo for anxiety and comorbid alcohol use disorders
Population: people with anxiety and comorbid alcohol use disorders
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment responseCGI‐I Paroxetine vs placebo | RR 2.23 [1.13, 4.41] | 2 studies · 57 participants | Very low Downgraded: indirectness, publication bias |
Symptom severity reductionLSAS Paroxetine vs placebo | no estimate extracted | 2 studies · 44 participants | Very low Downgraded: indirectness, publication bias |
Treatment acceptability Paroxetine vs placebo | RR 3.29 [0.14, 76.33] | 2 studies · 57 participants | Very low Downgraded: imprecision, inconsistency, indirectness, publication bias |
Proportion heavy drinking days Paroxetine vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Proportion of days abstinent Paroxetine vs placebo | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: indirectness, publication bias |
Drinks per drinking day Paroxetine vs placebo | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: indirectness, publication bias |
Depression symptom reduction Paroxetine vs placebo | no estimate extracted | 1 study · 15 participants | Very low |