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What do systematic reviews say?

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Evidence found and GRADE certainty

1,935 questions · 1,986 findings · 260 reviews · Headline outcomes only

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No studies found 503 · 25.3%GRADE not reported 76 · 3.8%Very low 593 · 29.9%Low 509 · 25.6%Moderate 241 · 12.1%High 64 · 3.2%

Multifactorial interventions vs usual care or attention control

Number of people who experienced one or more falls · Older people living in the community

Multifactorial interventions showed no clear difference in number of people sustaining one or more falls compared with usual care or attention control (low certainty).

1 finding from 1 review

Multifactorial interventions vs usual care or attention control

Number of people sustaining one or more fall‐related fractures · Older people living in the community

Multifactorial interventions showed no clear difference in number of people sustaining one or more fall‐related fractures compared with usual care or attention control (low certainty).

1 finding from 1 review

Testosterone vs other active intervention

Live birth · women undergoing assisted reproduction

It is very uncertain whether testosterone changes live birth ‐ Testosterone vs estradiol + OCP compared with other active interventions (very low certainty).

2 findings from 1 review

Testosterone vs other active intervention

Miscarriage · women undergoing assisted reproduction

It is very uncertain whether testosterone changes miscarriage ‐ Testosterone vs estradiol compared with other active interventions (very low certainty).

2 findings from 1 review

Testosterone vs other active intervention

Clinical pregnancy rate ‐ Testosterone vs estradiol · women undergoing assisted reproduction

It is very uncertain whether testosterone changes clinical pregnancy rate ‐ Testosterone vs estradiol compared with other active interventions (very low certainty).

1 finding from 1 review

Tailored interventions based on sputum eosinophils vs tailored interventions based on clinical symptoms

Exacerbations · people with asthma

Tailored interventions based on sputum eosinophils probably leads to lower number of participants who had one or more exacerbations over the… compared with tailored interventions based on clinical symptoms (moderate certainty).

1 finding from 1 review

An intervention in which one's attention is away from the experience of stress vs no intervention/wait list/placebo/no stress‐reduction intervention

Stress symptoms ( · healthcare workers
3 findings from 1 review

Multi‐component intervention vs control

Adverse events: number of people experiencing adverse events (all cause or COPD‐related), serious adverse events, mortality · COPD

Multi‐component intervention showed no clear difference in adverse events: number of people experiencing adverse events (all… compared with control (low certainty).

1 finding from 1 review

Multi‐component intervention vs control

Adherence to pharmacotherapy: number of people achieving adherence to medication · COPD

Multi‐component intervention may leads to higher adherence to pharmacotherapy: number of people achieving adherence… compared with control (low certainty).

1 finding from 1 review

Multi‐component intervention vs control

Exacerbations: number of people experiencing moderate or severe exacerbations · COPD

It is very uncertain whether multi‐component intervention changes exacerbations: number of people experiencing moderate or severe… compared with control (very low certainty).

1 finding from 1 review