Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,736 questions · 15,265 findings · 1,163 reviews · Headline outcomes only

No studies found 3,871 · 25.4%GRADE not reported 810 · 5.3%Very low 4,242 · 27.8%Low 3,879 · 25.4%Moderate 1,999 · 13.1%High 464 · 3%

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Pharmacological interventions vs placebo

acceptability ‐ drop‐outs due to adverse events: post‐intervention · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes acceptability ‐ drop‐outs due to adverse events: post‐intervention compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Acceptability · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes acceptability ‐ drop‐outs due to any cause: post‐intervention compared with placebo (very low certainty).

2 findings from 1 review

Pharmacological interventions vs placebo

Incidence of depression ‐ post‐intervention: 0 months · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes incidence of depression ‐ post‐intervention: 0 months compared with placebo (very low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Clinical recovery ‐ harmful or hazardous alcohol use (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use

Lay health worker‐led interventions for adult patients with harmful… showed no clear difference in clinical recovery ‐ harmful or hazardous alcohol use (1 to 6 months… compared with enhanced usual care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Prevalence of methamphetamine use (1 to 6 months post intervention) (RR < 1 denotes lower prevalence compared to control) · adult patients with harmful or hazardous alcohol or substance use

Lay health worker‐led interventions for adult patients with harmful… showed no clear difference in prevalence of methamphetamine use (1 to 6 months post intervention)… compared with enhanced usual care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) ‐ risk of hazardous or harmful alcohol use · adult patients with harmful or hazardous alcohol or substance use
1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Clinical symptoms ‐ alcohol and substance use (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use
1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Service utilisation ‐ unplanned hospitalisations (1 to 6 months post intervention) (RR < 1 denotes lower risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes service utilisation ‐ unplanned hospitalisations (1 to 6 months post… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Pharmacotherapy + behavioural support vs neither · smoking cessation in hospitalised patients

Hospital‐only intervention leads to higher pharmacotherapy + behavioural support vs neither compared with intervention that continues after hospital discharge (high certainty).

1 finding from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Behavioural support ‐ asynchronous** · smoking cessation in hospitalised patients

It is very uncertain whether hospital‐only intervention changes behavioural support ‐ asynchronous** compared with intervention that continues after hospital discharge (very low certainty).

1 finding from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Behavioural support ‐ synchronous** · smoking cessation in hospitalised patients

Hospital‐only intervention showed no clear difference in behavioural support ‐ synchronous** compared with intervention that continues after hospital discharge (low certainty).

1 finding from 1 review

Pharmacologic intervention vs another pharmacologic intervention

Harmful alcohol use ‐ not measured · alcohol use disorder

The review found no eligible studies for this question.

2 findings from 1 review

Pharmacologic intervention vs another pharmacologic intervention

Retention [ · alcohol use disorder

Pharmacologic intervention showed no clear difference in retention compared with another pharmacologic intervention (low certainty).

2 findings from 1 review