Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

311 questions · 316 findings · 105 reviews · Schizophrenia

No studies found 14 · 4.4%GRADE not reported 11 · 3.5%Very low 143 · 45.3%Low 79 · 25%Moderate 66 · 20.9%High 3 · 0.9%

CLOZAPINE + ARIPIPRAZOLE vs CLOZAPINE + HALOPERIDOL (Cipriani 2013)

Acceptability of treatment ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + ARIPIPRAZOLE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + HALOPERIDOL (Cipriani 2013) (very low certainty).

1 finding from 1 review

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs HIGH DOSE (> 800 mg/day ‐ all medium term)

Behaviour: deterioration of behaviour (categorised as reason to leave early) · schizophrenia

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) may leads to higher behaviour: deterioration of behaviour (categorised as reason to… compared with HIGH DOSE (> 800 mg/day ‐ all medium term) (low certainty).

1 finding from 1 review

CHLORPROMAZINE vs Clotiapine

Leaving the study early · patients with schizophrenia

It is very uncertain whether chlorpromazine changes leaving the study early: for any reason compared with clotiapine (very low certainty).

1 finding from 1 review

Intervention not reported

Leaving the study early: any reason (medium term) · patients with schizophrenia

The intervention showed no clear difference in leaving the study early: any reason (medium term) (low certainty).

1 finding from 1 review

Yoga vs NON‐STANDARD CARE

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

YOGA probably leads to lower leaving the study early: short term compared with NON‐STANDARD CARE (moderate certainty).

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Leaving the study early · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Oral health education (advice and training) showed no clear difference in leaving the study early compared with standard care (oral health advice not specifically emphasised beyond… (moderate certainty).

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Leaving the study early · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Motivational interview plus oral health education showed no clear difference in leaving the study early compared with oral health education (moderate certainty).

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Leaving the study early · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Monitoring (any means of observation, supervision, keeping under… showed no clear difference in leaving the study early compared with no monitoring (moderate certainty).

1 finding from 1 review

VALPROATE + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether VALPROATE + ANTIPSYCHOTICS changes leaving the study early: Acceptability of treatment Leaving the… compared with ANTIPSYCHOTICS + PLACEBO or ANTIPSYCHOTICS alone (very low certainty).

1 finding from 1 review

VALPROATE + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

VALPROATE + ANTIPSYCHOTICS showed no clear difference in leaving the study early: Overall tolerability Leaving the study… compared with ANTIPSYCHOTICS + PLACEBO or ANTIPSYCHOTICS alone (low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs RISPERIDONE

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in leaving the study early: Any reason ‐ short term compared with ORAL RISPERIDONE (moderate certainty).

1 finding from 1 review