Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

592 questions · 618 findings · 64 reviews · Headline outcomes only

No studies found 116 · 18.8%GRADE not reported 59 · 9.5%Very low 206 · 33.3%Low 158 · 25.6%Moderate 79 · 12.8%High 0 · 0%

Therapist‐supported ICBT vs waiting list, attention, information, or online discussion group only control

Clinically important improvement in anxiety at post‐treatment Indexed by a standardized interview or clinically accepted measure cut‐off score1 · patients with anxiety disorders

Therapist‐supported ICBT may leads to higher clinically important improvement in anxiety at post‐treatment… compared with waiting list, attention, information, or online discussion group… (low certainty).

1 finding from 1 review

CBT plus standard care vs usual care

Global state: 2. Clinically important change (no improvement) ‐ long term · patients with schizophrenia

It is very uncertain whether COMPARISON 1: CBT+ STANDARD CARE changes global state: 2. Clinically important change (no improvement) ‐ long… compared with STANDARD CARE ALONE (very low certainty).

1 finding from 1 review

CBT plus standard care vs usual care

Mental state: General ‐ clinically important change (no improvement) · patients with schizophrenia

It is very uncertain whether COMPARISON 1: CBT+ STANDARD CARE changes mental state: General ‐ clinically important change (no improvement)… compared with STANDARD CARE ALONE (very low certainty).

1 finding from 1 review

CBT plus standard care vs usual care

Adverse events experienced at short or long term ‐ general adverse events 24 weeks' · patients with schizophrenia

It is very uncertain whether COMPARISON 1: CBT+ STANDARD CARE changes adverse events: General: any adverse event compared with STANDARD CARE ALONE (very low certainty).

1 finding from 1 review

CBT plus standard care vs usual care

Satisfaction with treatment: 1. Leaving the study early ‐ long term · patients with schizophrenia

COMPARISON 1: CBT+ STANDARD CARE showed no clear difference in satisfaction with treatment: 1. Leaving the study early ‐ long term compared with STANDARD CARE ALONE (moderate certainty).

1 finding from 1 review