Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,289 questions · 2,331 findings · 195 reviews · Pregnancy and Childbirth

No studies found 480 · 20.6%GRADE not reported 288 · 12.4%Very low 467 · 20%Low 630 · 27%Moderate 338 · 14.5%High 128 · 5.5%

Chlorhexidine vaginal wash vs placebo

Blood culture confirming neonatal sepsis Clinical findings and confirmation by laboratory · Pregnant women with a gestational age greater than 28 weeks, considered to be in labour receiving chlorhexidine vaginal douching during…

Chlorhexidine vaginal wash showed no clear difference in blood culture confirming neonatal sepsis Clinical findings and… compared with placebo (low certainty).

1 finding from 1 review

Ambroxol vs corticosteroid (betamethasone)

Perinatal mortality frequency of deaths of newborns · women at risk of preterm birth

Ambroxol showed no clear difference in perinatal mortality frequency of deaths of newborns compared with corticosteroid (betamethasone) (moderate certainty).

1 finding from 1 review

Ambroxol vs placebo or no treatment

Other events in newborns ‐ Administration of pulmonary surfactant frequency in newborns · women at risk of preterm birth

Ambroxol showed no clear difference in other events in newborns ‐ Administration of pulmonary surfactant… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Ambroxol vs placebo or no treatment

Other events in newborns ‐ Need for mechanical ventilation frequency inf newborns · women at risk of preterm birth

Ambroxol showed no clear difference in other events in newborns ‐ Need for mechanical ventilation frequency… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Intervention not reported

Respiratory distress Respiratory rate at rest > 60/min and/or signs of respiratory distress. · pregnant women at term.

The intervention may leads to lower respiratory distress Respiratory rate at rest > 60/min and/or signs… (low certainty).

1 finding from 1 review

AFI vs SDVP: summary of findings table

Admission to neonatal intensive care unit · pregnant women to prevent adverse pregnancy outcome

AFI showed no clear difference in admission to neonatal intensive care unit compared with SDVP: summary of findings table (moderate certainty).

1 finding from 1 review

AFI vs SDVP: summary of findings table

Rate of diagnosis of oligohydramnios · pregnant women to prevent adverse pregnancy outcome

AFI probably leads to higher rate of diagnosis of oligohydramnios compared with SDVP: summary of findings table (moderate certainty).

1 finding from 1 review