Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Oral Health

No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Machine-learning algorithms for dental caries detection vs Different machine-learning algorithms for caries prediction

detection of proximal caries · Dental images of human beings

The review reported 85.6% accuracy for proximal caries in Casalegno et al. (Ungraded).

2 findings from 1 review

Caries in first and second primary molars vs Reference (other primary tooth locations / caries-free)

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Caries in the first and second primary molars is the strongest tooth-specific predictor of caries in permanent teeth (RR 3.4; single study; not GRADE-rated).

1 finding from 1 review

Selective carious tissue removal (selective excavation, SE) vs Non-selective or complete carious tissue removal

Pulp exposure during caries removal · Children with dentine caries in primary and permanent teeth

Partial caries removal was reported to reduce pulp-exposure risk by 77% versus complete caries removal (RR 0.23; ungraded).

1 finding from 1 review

Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Glass-ionomer cement bonded to sound dentin (in vitro)

SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD -1.11 MPa, 95% CI -3.47 to 1.25; ungraded).

1 finding from 1 review

Atraumatic restorative treatment plus fluoride varnish vs Silver diamine fluoride plus fluoride varnish

Oral health-related quality of life · Children with dental caries

The direct estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment plus fluoride varnish and silver diamine fluoride plus fluoride varnish.

2 findings from 1 review

Machine-learning algorithms for dental caries detection vs Different machine-learning algorithms for caries prediction

Occlusal caries detection accuracy · Dental images of human beings

The review reported 66.7% accuracy for the worst class in Moutselos et al. (Ungraded).

4 findings from 1 review
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SDF applied biannually (every 6 months) vs Other non/minimally-invasive treatment (ART or 5% NaF varnish)

Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars

Biannual SDF application significantly arrested caries (pooled ES 0.39, 95% CI 0.19-0.60; ungraded).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART)

Oral health-related quality of life · Children with dental caries

SDF did not significantly differ from atraumatic restorative treatment for oral health-related quality of life (MD 0.02, 95% CI -0.32 to 0.36; ungraded).

1 finding from 1 review

Primary dentition DMFT score 1-3 vs No caries in primary teeth (DMFT = 0)

Caries prevalence in permanent dentition · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

A primary-dentition DMFT of 1-3 is associated with 1.5 times higher risk of caries in permanent teeth (single study; not GRADE-rated).

1 finding from 1 review

Selective caries removal (SCR) + composite resin vs Complete caries removal (CCR) + composite resin

Treatment failure (annual failure rate) · Children with deep dentine caries in primary molars restored with composite resin (indirect pulp treatment; pulpotomy only if pulp exposed…

Complete caries removal with composite resin had an annual failure rate of 6.8% in primary molars (single high-risk-of-bias RCT; low quality of evidence; not GRADE-rated).

2 findings from 1 review

Caregiver help with child tooth brushing vs Not applicable (single-group prevalence)

Caregiver help with tooth brushing prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 54% of children with caries in LMICs received caregiver help with tooth brushing (pooled prevalence 0.541, 95% CI 0.266 to 0.803; 3 studies; not GRADE-rated).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in recurrent oral ulceration between ART regimens (very low certainty).

1 finding from 1 review

Preformed metal crown (PMC) vs Resin-modified glass-ionomer cement + composite resin (modified open-sandwich restoration)

Restoration failure · Children with carious primary teeth after vital or non-vital pulp therapy

In one RCT, preformed metal crowns had an annual failure rate of 2.5% after 2 years.

1 finding from 1 review

Female sex vs Not applicable (single-group prevalence)

Female sex prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

Among children with caries in LMICs, about half were female (pooled prevalence 0.497, 95% CI 0.475 to 0.519; 6 studies; I2=0%; not GRADE-rated).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Dental caries prevalence · Children or adolescents

In permanent dentition, CLWH on ART had higher caries prevalence than healthy controls (OR 2.49, 95% CI 1.86 to 3.32; single study).

3 findings from 1 review

Resin infiltration vs Baseline before resin infiltration

Color change · Patients with post-orthodontic white spot lesions and permanent dentition

Eckstein (2015) reported a statistically significant color-change effect.

4 findings from 1 review
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