Early childhood caries (ECC) - association at lead SNP rs7325099 (13:28104496; nearest gene(s) LNX2, POLR1D, RPL21) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs7325099 near LNX2, POLR1D, RPL21 showed suggestive (not genome-wide significant) association with ECC (Z = 4.485, p = 7.28e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of LACC1 (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted LACC1 expression reached the TWAS threshold for ECC (p = 3.98e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of NRAD1 (LINC00284) (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted NRAD1 (LINC00284) expression reached the TWAS threshold for ECC (p = 1.69e-6) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R31 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R31 was suggestively associated with ECC in the TWAS (p = 1.04e-5); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R14 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R14 was significantly associated with ECC in the TWAS (p = 1.06e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
No significant difference in caries odds was found between bottle-fed-only and breast-fed-only children (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of IGSF5 (chr21q22.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted IGSF5 expression reached the TWAS threshold for ECC (p = 7.22e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
No significant difference in caries odds was found between children of low- versus high-SES parents (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of LINC02905 (C8orf49) (chr8p23.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted LINC02905 (C8orf49) expression reached the TWAS threshold for ECC (p = 1.82e-8) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs74470773 (3:33958083; nearest gene(s) PDCD6IP) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs74470773 near PDCD6IP showed suggestive (not genome-wide significant) association with ECC (Z = -4.589, p = 4.46e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of CDH17 (chr8q22.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of CDH17 was significantly associated with ECC in the TWAS (p = 3.32e-8); genetic association, ungraded.
1 finding from 1 review
Caries prevalence (early childhood caries) · Toddlers and preschool children, 2 to 6 years of age (primary dentition)
Caesarean section delivery may be associated with a modestly higher prevalence of early childhood caries than vaginal delivery (pooled OR 1.48), but the evidence is inconsistent and of very low certainty.
1 finding from 1 review
Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
Adjusted analyses also showed no association between low birth weight and early childhood caries (adjusted OR 1.05, 95% CI 0.71 to 1.57); certainty not graded.
3 findings from 1 review
Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
In children aged 3 years or younger, preterm birth was not associated with early childhood caries (OR 0.90, 95% CI 0.59 to 1.37); certainty not graded.
2 findings from 1 review
Stage at diagnosis (early-stage detection) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
Visual screening (oral visual inspection) by trained health workers led to lower stage at diagnosis (early-stage detection) compared with no screening; GRADE not reported.
2 findings from 1 review
Success of the anchorage device · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage
Early loading of mini-screw implant showed no clear difference in success of the anchorage device compared with delayed loading of mini-screw implant; GRADE not reported.
1 finding from 1 review
PAR score · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)
Early treatment (two-phase) with headgear showed no clear difference in PAR score compared with late treatment (one-phase in adolescence) with headgear; GRADE not reported.
1 finding from 1 review
Incidence of new incisal trauma · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)
Early treatment (two-phase) with headgear may leads to lower incidence of new incisal trauma compared with late treatment (one-phase in adolescence) with headgear (low certainty).
1 finding from 1 review
Final overjet · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)
Early treatment (two-phase) with headgear showed no clear difference in final overjet compared with late treatment (one-phase in adolescence) with headgear (low certainty).
2 findings from 1 review
Incidence of incisal trauma · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)
Early treatment (two-phase) with headgear showed no clear difference in incidence of incisal trauma compared with late treatment (one-phase in adolescence) with headgear; GRADE not reported.
1 finding from 1 review