Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Very early discharge vs early discharge

Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both) in number of episodes · children with cancer

Very early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with early discharge (low certainty).

1 finding from 1 review

Very early discharge vs early discharge

Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both), only first episode in number of participants · children with cancer

Very early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with early discharge (low certainty).

1 finding from 1 review

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Death Analysis 1.1 · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in all‐cause mortality, ITT analysis compared with early conservative management with or without delayed or selective… (low certainty).

1 finding from 1 review

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Local complications defined by the Atlanta Classification (necrosis, abscess, pseudocyst) · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in local complications defined by the Atlanta Classification (necrosis,… compared with early conservative management with or without delayed or selective… (moderate certainty).

1 finding from 1 review

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Systemic complications defined by the Atlanta Classification (organ failure including shock, pulmonary insufficiency, renal failure, and gastrointestinal bleeding; disseminated intravascular coagulation or severe metabolic disturbances) · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in systemic complications defined by the Atlanta Classification (organ… compared with early conservative management with or without delayed or selective… (moderate certainty).

1 finding from 1 review

Early ART vs delayed ART initiation

HIV virological suppression at 6 months (viral load < 400 copies/mL) · HIV‐positive people with cryptococcal meningitis

It is very uncertain whether early ART changes HIV virological suppression at 6 months (viral load < 400 copies/mL) compared with delayed ART initiation (very low certainty).

1 finding from 1 review

Early surgery vs late surgery

Complete recovery of facial nerve function at 12 months Defined as: complete recovery HB grade I. · Bell's palsy

It is very uncertain whether early surgery changes complete recovery of facial nerve function at 12 months Defined as:… compared with late surgery (very low certainty).

1 finding from 1 review

Early discharge vs standard discharge

Number of infants having contact with healthcare professionals regarding infant health issues within 4 weeks of birth · healthy mothers and term infants

Early discharge showed no clear difference in number of infants having contact with healthcare professionals… compared with standard discharge (moderate certainty).

1 finding from 1 review